Document Detail

Efficacy of indomethacin 0.1% and fluorometholone 0.1% on conjunctival inflammation following chronic application of antiglaucomatous drugs.
MedLine Citation:
PMID:  12486516     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Subclinical conjunctival inflammation has been shown to have a deleterious effect on the outcome of filtering surgery. The study was designed to assess the efficacy and safety of a non-steroidal anti-inflammatory ophthalmic solution (preservative-free indomethacin 0.1%) on conjunctival inflammation following chronic application of antiglaucomatous drugs, in comparison with a steroidal ophthalmic solution (preserved fluorometholone). METHODS: Eighty-nine glaucomatous patients were included in a randomised, multicentre study comparing two parallel groups of treatment given on the basis of 1 drop 4 times daily for 1 month before filtering surgery. Patients had been treated with one or more antiglaucomatous drugs for at least 3 years. The routine antiglaucomatous treatment was continued during the study. Evaluations were carried out at baseline and after 30 days of treatment. Conjunctival inflammation was assessed under masked conditions by means of conjunctival impression analysis which determined the percentage of cells expressing HLA-DR. The ocular surface was also examined using the fluorescein test and lissamine green staining. RESULTS: Paired conjunctival impression specimens available both on day 0 (D0) and day 30 (D30) involved 49 patients. Among them, 34 eyes had a positive expression of HLA-DR at inclusion. On D30, in patients positive to HLA-DR on D0, the percentage of cells expressing HLA-DR had significantly decreased in both treatment groups: the mean reduction was 29.7% from a baseline value of 51.4% in the indomethacin group ( P=0.019) and 32.5% from a baseline value of 48.7% in the fluorometholone group ( P<0.001). There was no significant difference between groups. Seven cases of drug-related superficial punctate keratitis were observed on D30 by means of a fluorescein test: one in the indomethacin group and six in the fluorometholone group. CONCLUSION: Both anti-inflammatory eyedrops were effective in reducing subclinical conjunctival inflammation before filtering surgery. Regarding superficial punctate keratitis, the corneal tolerance of preservative-free indomethacin 0.1% eyedrops seemed to be better than that of preserved fluorometholone eyedrops.
Christophe Baudouin; Jean-Philippe Nordmann; Philippe Denis; Catherine Creuzot-Garcher; Catherine Allaire; Claude Trinquand
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2002-10-30
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  240     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  929-35     Citation Subset:  IM    
Hôpital A. Paré, Boulogne-Billancourt, France.
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MeSH Terms
Anti-Inflammatory Agents / adverse effects,  therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  therapeutic use*
Chronic Disease
Conjunctiva / immunology
Conjunctivitis / complications,  drug therapy*,  immunology
Fluorometholone / adverse effects,  therapeutic use*
Glaucoma / complications,  drug therapy
HLA-DR Antigens / metabolism
Indomethacin / adverse effects,  therapeutic use*
Keratitis / chemically induced
Middle Aged
Ophthalmic Solutions / therapeutic use
Prospective Studies
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/HLA-DR Antigens; 0/Ophthalmic Solutions; 426-13-1/Fluorometholone; 53-86-1/Indomethacin

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