Document Detail


Efficacy in angiotensin receptor blockade: a comparative review of data with olmesartan.
MedLine Citation:
PMID:  19651759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A range of angiotensin II receptor blockers (ARB) is available, and analyses suggest there are differences between agents in terms of antihypertensive efficacy and 24-hour blood pressure control.This review assesses the data comparing olmesartan with other ARBs in terms of blood pressure reductions, goal achievement, 24-hour control and speed of onset. Olmesartan seems to have a more favourable efficacy profile relative to standard doses of the ARBs used in comparative studies; results consistent with the high degree of blockade of the angiotensin II type 1 receptor for olmesartan.Taken together, there might be differences between ARBs regarding their blood pressure lowering efficacy, and these results may provide further support of the benefits of olmesartan therapy since choice of an effective agent is crucial in antihypertensive therapy.
Authors:
Josep Redon; Maria Jose Fabia
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2009-08-03
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  10     ISSN:  1752-8976     ISO Abbreviation:  J Renin Angiotensin Aldosterone Syst     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
Affiliation:
Hypertension Clinic, Hospital Cl??nico Universitario, University of Valencia, Valencia, Spain. josep.redon@uv.es
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Drug Therapy, Combination
Humans
Imidazoles / chemistry,  pharmacology*
Receptors, Angiotensin / antagonists & inhibitors*,  chemistry
Tetrazoles / chemistry,  pharmacology*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Imidazoles; 0/Receptors, Angiotensin; 0/Tetrazoles; 0/olmesartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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