Document Detail

Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour.
MedLine Citation:
PMID:  15760313     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy and safety of hyoscine-N-butyl bromide (Buscopan) suppositories in the active phase of labour, i.e. once the labour is established. METHODS: A non-randomised controlled prospective study was carried out on 200 women in labour. In the active phase of labour, at 3 cm or more cervical dilatation, 100 women were administered Buscopan via suppository and 100 women (control) were not given any drug. RESULTS: The duration of first stage of labour was 123.86 +/- 68.89 (mean(+)-standard deviation) minutes in the study group and 368.05 +/- 133.0 min in the control group. These differences were statistically significant. There were no differences in the duration of the second and third stages of labour. There was no increased incidence of operative deliveries in the study group. No adverse effects were noted on the mother or fetus. CONCLUSION: Hyoscine-N-butyl bromide (HBB, Buscopan) suppositories were highly effective in shortening the duration of the first stage of labour.
Daya Sirohiwal; Krishna Dahiya; Mandira De
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  45     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-11     Completed Date:  2005-08-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  128-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Sciences, Haryana, India.
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MeSH Terms
Administration, Intravaginal
Butylscopolammonium Bromide / administration & dosage*
Labor Stage, First / drug effects*
Parasympatholytics / administration & dosage*
Prospective Studies
Suppositories / administration & dosage
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Parasympatholytics; 0/Suppositories; 149-64-4/Butylscopolammonium Bromide

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