| Efficacy of homeopathically potentized antimony on blood coagulation. A randomized placebo controlled crossover trial. | |
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MedLine Citation:
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PMID: 19295225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Homeopathically potentized antimony 6x is traditionally used in anthroposophic medicine for an alleged pro-coagulatory effect in bleeding disorders. However, the scientific evidence base is yet insufficient. Results of a previous in vitro study suggested a slight increase of maximal clot firmness (MCF) and a tendency towards a shorter clotting time (CT). The objective of this study was to investigate the pro-coagulatory effects of antimony in vivo, and possible unexpected or adverse events. PARTICIPANTS AND METHODS: A randomized placebo controlled double blind crossover study was carried out in 30 healthy volunteers (15 males, 15 females). Each participant received intravenously 10 ml of antimony 6x and placebo in a randomized order at an interval of 1 month. Thrombelastography (TEG) was carried out immediately before and 30 and 60 min after the injection. RESULTS: Statistically significant pro-coagulatory effects were observed 30 min after injection for CT in men (p = 0.0306), and for MCF in men and women combined (p = 0.0476). The effect of antimony was significantly larger on test day 1 than on test day 2, whereas the effect of placebo was similar on both test days. No unexpected adverse or adverse events causally related to antimony were observed. CONCLUSION: This study adds evidence to the hypothesis that homeopathically potentized antimony may be efficacious in vivo. The consistency of the results with previous in vitro results indicates an effect on MCF and CT. The in vivo application of antimony 6x is safe. |
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Authors:
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Peter Heusser; Sarah Berger; Monika Stutz; André Hüsler; André Haeberli; Ursula Wolf |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-02-10 |
Journal Detail:
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Title: Forschende Komplementärmedizin (2006) Volume: 16 ISSN: 1661-4127 ISO Abbreviation: - Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-03-19 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269884 Medline TA: Forsch Komplementmed Country: Switzerland |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Anthroposophic Medicine, Institute of Complementary Medicine KIKOM, University of Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimony / adverse effects, therapeutic use* Blood Coagulation / drug effects* Coagulants / adverse effects, therapeutic use* Cross-Over Studies Female Humans Male Materia Medica / adverse effects, therapeutic use* Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Coagulants; 0/Materia Medica; 7440-36-0/Antimony |
| Comments/Corrections | |
Comment In:
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Forsch Komplementmed. 2009 Jun;16(3):196; author reply 196
[PMID:
19657206
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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