Document Detail


Efficacy of high doses of Botulinum toxin A for treating provoked vestibulodynia.
MedLine Citation:
PMID:  21275944     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Provoked vestibulodynia is difficult to treat. The beneficial effects of botulinum toxin are being considered due to the muscular anomalies observed in this pathology. Objective:  We aim to evaluate the efficacy of botulinum toxin A in the treatment of provoked vestibulodynia. Methods:  Patients aged between 18 and 60 presenting with provoked vestibulodynia (according to the 2003 ISSVD classification) received 50 units of botulinum toxin A bilaterally in the bulbospongiosus muscle under electromyographic monitoring. Pain was evaluated by a visual analogue scale, quality of life was evaluated by the Dermatology Life Quality Index and sexual function by the Female Sexual Function Index. Results:  Twenty patients received the injections. Sixteen patients presented with a muscular hyperactivity on the electromyogram. After 3 months, 80% patients improved in terms of pain. Mean VAS values significantly decreased from 8.37 ± 0.95, (extreme values: 4.5-10) to 2.57 ± 2.17 (0-9; p<0.0001) at month 3 and to 3.90 ± 3.01 (0-9; p<0.001) at month 6. Quality of life and sexual function improved significantly during the first 6 months (p<0.0001). After 3 months, 15 patients (72%) were able to have sexual intercourse. Conclusion:  BTA seems to be an effective and safe treatment for treating PV because 100 U botulinum toxin A significantly reduced pain 3 and 6 months after injections without side effects. The treatment improved also quality of life and sexual function of patients. BTA appears to be a promising option for managing sexual pain disorder.
Authors:
F Pelletier; B Parratte; S Penz; J-P Moreno; F Aubin; P Humbert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-28
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Affiliation:
Université de Franche-Comté, UMR 645, IFR 133, Besançon, France Centre Hospitalier Universitaire, Service de Dermatologie, Besançon, France Centre d'Investigation Clinique en Biothérapie, Besançon, France Laboratoire d'anatomie-Université de Franche-Comté, EA 3920, IFR 133, Besançon, France Centre Hospitalier Universitaire, Service de Médecine Physique et Réadaptation, Besançon, France Université de Franche-Comté, Département de Médecine Générale, Besançon, France Université de Franche-Comté, EA 3181, IFR 133, Besançon, France.
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