| Efficacy of high-concentration tacalcitol ointment in psoriasis vulgaris after changing from other high-concentration vitamin D3 ointments. | |
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MedLine Citation:
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PMID: 18700105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three high-concentration vitamin D3 ointments are currently available in Japan for the treatment of psoriasis. The aim of the present study is to investigate the efficacy of high-concentration tacalcitol in patients with psoriasis vulgaris who have already been treated with another high-concentration vitamin D3 ointment, calcipotriol or maxacalcitol. The psoriasis area and severity index score was improved in more than half the patients after changing to the tacalcitol ointment. Many patients treated with maxacalcitol once a day achieved greater clinical improvement by changing to high-concentration tacalcitol. In contrast, some patients who had responded to a high-concentration tacalcitol ointment showed exacerbation after changing to maxacalcitol once a day. Interviews with 50 patients (including the 34 patients enrolled in the present study) indicated that high-concentration tacalcitol ointment was an acceptable therapy in terms of the number of daily applications and drug cost. The results of this clinical study suggest that high-concentration tacalcitol ointment meets the preference of many patients who wish to use an ointment once a day. |
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Authors:
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Tomoko Syuto; Hirohisa Ishibuchi; Yoko Sogabe; Yoko Yokoyama; Osamu Ishikawa |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article Date: 2008-02-28 |
Journal Detail:
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Title: Dermatology online journal Volume: 14 ISSN: 1087-2108 ISO Abbreviation: Dermatol. Online J. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-13 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610776 Medline TA: Dermatol Online J Country: United States |
Other Details:
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Languages: eng Pagination: 2 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Gunma University Graduate School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcitriol
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administration & dosage,
analogs & derivatives*,
economics,
therapeutic use Dihydroxycholecalciferols / administration & dosage, economics, therapeutic use* Drug Administration Schedule Humans Ointments Patient Acceptance of Health Care Prescription Fees Psoriasis / drug therapy* Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dihydroxycholecalciferols; 0/Ointments; 103909-75-7/maxacalcitol; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol; 60965-80-2/1 alpha,24-dihydroxyvitamin D3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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