Document Detail

Efficacy of high-concentration tacalcitol ointment in psoriasis vulgaris after changing from other high-concentration vitamin D3 ointments.
MedLine Citation:
PMID:  18700105     Owner:  NLM     Status:  MEDLINE    
Three high-concentration vitamin D3 ointments are currently available in Japan for the treatment of psoriasis. The aim of the present study is to investigate the efficacy of high-concentration tacalcitol in patients with psoriasis vulgaris who have already been treated with another high-concentration vitamin D3 ointment, calcipotriol or maxacalcitol. The psoriasis area and severity index score was improved in more than half the patients after changing to the tacalcitol ointment. Many patients treated with maxacalcitol once a day achieved greater clinical improvement by changing to high-concentration tacalcitol. In contrast, some patients who had responded to a high-concentration tacalcitol ointment showed exacerbation after changing to maxacalcitol once a day. Interviews with 50 patients (including the 34 patients enrolled in the present study) indicated that high-concentration tacalcitol ointment was an acceptable therapy in terms of the number of daily applications and drug cost. The results of this clinical study suggest that high-concentration tacalcitol ointment meets the preference of many patients who wish to use an ointment once a day.
Tomoko Syuto; Hirohisa Ishibuchi; Yoko Sogabe; Yoko Yokoyama; Osamu Ishikawa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2008-02-28
Journal Detail:
Title:  Dermatology online journal     Volume:  14     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2     Citation Subset:  IM    
Department of Dermatology, Gunma University Graduate School of Medicine, Japan.
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MeSH Terms
Calcitriol / administration & dosage,  analogs & derivatives*,  economics,  therapeutic use
Dihydroxycholecalciferols / administration & dosage,  economics,  therapeutic use*
Drug Administration Schedule
Patient Acceptance of Health Care
Prescription Fees
Psoriasis / drug therapy*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Dihydroxycholecalciferols; 0/Ointments; 103909-75-7/maxacalcitol; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol; 60965-80-2/1 alpha,24-dihydroxyvitamin D3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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