| Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity. | |
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MedLine Citation:
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PMID: 21095107 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85mg/kg BW) twice at an interval of 24h, for two consecutive days. HDN was administered by post-orally at a dose of 200mg/kg BW. The results showed increased levels of plasma cholesterol, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) and decreased level of high density lipoprotein-cholesterol (HDL-C) in ISO-induced rats. ISO rats also showed an increase in cholesterol, TG and FFA and decrease in PL levels in the heart and liver tissues. HDN treatment brought the above parameters towards normal level. This experiment shows that HDN possesses hypolipidemic effect in ISO-induced rats. |
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Authors:
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Palanisamy Selvaraj; Kodukkur Viswanathan Pugalendi |
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Publication Detail:
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Type: Journal Article Date: 2010-11-20 |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 64 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-05-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
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Languages: eng Pagination: 449-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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