| Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. | |
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MedLine Citation:
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PMID: 10584049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system. OBJECTIVE: We investigated whether a green tea extract, by virtue of its high content of caffeine and catechin polyphenols, could increase 24-h energy expenditure (EE) and fat oxidation in humans. DESIGN: Twenty-four-hour EE, the respiratory quotient (RQ), and the urinary excretion of nitrogen and catecholamines were measured in a respiratory chamber in 10 healthy men. On 3 separate occasions, subjects were randomly assigned among 3 treatments: green tea extract (50 mg caffeine and 90 mg epigallocatechin gallate), caffeine (50 mg), and placebo, which they ingested at breakfast, lunch, and dinner. RESULTS: Relative to placebo, treatment with the green tea extract resulted in a significant increase in 24-h EE (4%; P < 0.01) and a significant decrease in 24-h RQ (from 0.88 to 0.85; P < 0.001) without any change in urinary nitrogen. Twenty-four-hour urinary norepinephrine excretion was higher during treatment with the green tea extract than with the placebo (40%, P < 0.05). Treatment with caffeine in amounts equivalent to those found in the green tea extract had no effect on EE and RQ nor on urinary nitrogen or catecholamines. CONCLUSIONS: Green tea has thermogenic properties and promotes fat oxidation beyond that explained by its caffeine content per se. The green tea extract may play a role in the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both. |
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Authors:
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A G Dulloo; C Duret; D Rohrer; L Girardier; N Mensi; M Fathi; P Chantre; J Vandermander |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 70 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 1999-12-20 Completed Date: 1999-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1040-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, University of Geneva. abdul.dulloo@unifr.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects*,
metabolism Adult Caffeine / pharmacology* Catechin / pharmacology* Central Nervous System Stimulants / pharmacology* Circadian Rhythm Energy Metabolism / drug effects* Humans Lipid Metabolism Male Obesity / urine Oxidation-Reduction Plant Extracts / pharmacology Tea* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 0/Plant Extracts; 0/Tea; 154-23-4/Catechin; 58-08-2/Caffeine |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2000 Nov;72(5):1232-4
[PMID:
11063454
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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