Document Detail

Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.
MedLine Citation:
PMID:  10584049     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system. OBJECTIVE: We investigated whether a green tea extract, by virtue of its high content of caffeine and catechin polyphenols, could increase 24-h energy expenditure (EE) and fat oxidation in humans. DESIGN: Twenty-four-hour EE, the respiratory quotient (RQ), and the urinary excretion of nitrogen and catecholamines were measured in a respiratory chamber in 10 healthy men. On 3 separate occasions, subjects were randomly assigned among 3 treatments: green tea extract (50 mg caffeine and 90 mg epigallocatechin gallate), caffeine (50 mg), and placebo, which they ingested at breakfast, lunch, and dinner. RESULTS: Relative to placebo, treatment with the green tea extract resulted in a significant increase in 24-h EE (4%; P < 0.01) and a significant decrease in 24-h RQ (from 0.88 to 0.85; P < 0.001) without any change in urinary nitrogen. Twenty-four-hour urinary norepinephrine excretion was higher during treatment with the green tea extract than with the placebo (40%, P < 0.05). Treatment with caffeine in amounts equivalent to those found in the green tea extract had no effect on EE and RQ nor on urinary nitrogen or catecholamines. CONCLUSIONS: Green tea has thermogenic properties and promotes fat oxidation beyond that explained by its caffeine content per se. The green tea extract may play a role in the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both.
A G Dulloo; C Duret; D Rohrer; L Girardier; N Mensi; M Fathi; P Chantre; J Vandermander
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  70     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-20     Completed Date:  1999-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1040-5     Citation Subset:  AIM; IM    
Department of Physiology, Faculty of Medicine, University of Geneva.
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MeSH Terms
Adipose Tissue / drug effects*,  metabolism
Caffeine / pharmacology*
Catechin / pharmacology*
Central Nervous System Stimulants / pharmacology*
Circadian Rhythm
Energy Metabolism / drug effects*
Lipid Metabolism
Obesity / urine
Plant Extracts / pharmacology
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Plant Extracts; 0/Tea; 154-23-4/Catechin; 58-08-2/Caffeine
Comment In:
Am J Clin Nutr. 2000 Nov;72(5):1232-4   [PMID:  11063454 ]

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