| Efficacy of granulocyte transfusions collected from nonstimulated donors. | |
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MedLine Citation:
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PMID: 7100219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Series of leukocyte transfusions were given to adult patients with previously untreated acute non-lymphocytic leukemia during the granulocytopenic phase of remission induction therapy with doxorubicin and cytosine arabinoside. Peripheral blood leukocytes for transfusion were obtained by continuous flow centrifugation from unstimulated normal persons. Forty-five consecutive patients were eligible to receive leukocyte transfusions depending upon the availability of the blood cell separator for leukapheresis of donors and, to a lesser extent, clinical need. A series of leukocyte transfusions was given to 28 patients; 17 patients did not receive leukocyte transfusions. Patients in both groups were similar with respect to variables known to have prognostic value. The clinical outcomes of the patients in both series were similar. Fifteen of the 28 patients receiving leukocyte transfusions had a temperature response detected by cumulative summation. Fourteen of these patients also had other evidence of clinical improvement compared with only five of ten patients not demonstrating a temperature response during a series of leukocyte transfusions 0.50 greater than P 0.025). This study suggests that leukocyte transfusions from unstimulated normal donors are effective in the management of patients with potentially reversible granulocytopenia. |
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Authors:
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J E Curtis |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Progress in clinical and biological research Volume: 88 ISSN: 0361-7742 ISO Abbreviation: Prog. Clin. Biol. Res. Publication Date: 1982 |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605701 Medline TA: Prog Clin Biol Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 61-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Agranulocytosis / therapy Blood Donors* Blood Transfusion Centrifugation Cytarabine / therapeutic use Doxorubicin / therapeutic use Fever Humans Leukapheresis / methods Leukemia / therapy* Leukocyte Transfusion* Middle Aged Premedication |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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