| Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. | |
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MedLine Citation:
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PMID: 7627502 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intact intestinal epithelium and associated lymphatic tissue act as body defences against luminal toxins. This barrier may become threatened or compromised in inflammatory bowel disease, leading to an increase in mucosal permeability and subsequent translocation of endotoxins. The effect of oral glutamine on gut mucosal ornithine decarboxylase activity and on endotoxin levels in portal vein blood was studied in a guinea-pig model of carrageenan-induced colitis. Despite failure to show induction of ornithine decarboxylase activity by glutamine administration, the mean endotoxin level of portal vein blood in guinea-pigs fed a glutamine-enriched elemental diet was 25.3 pg/ml compared with 71.2 pg/ml in animals given a standard elemental diet (P < 0.01). A glutamine-enriched elemental diet may be therapeutically beneficial in patients with inflammatory bowel disease. |
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Authors:
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T Fujita; K Sakurai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 82 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-09-05 Completed Date: 1995-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 749-51 Citation Subset: AIM; IM |
Affiliation:
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First Department of Surgery, Jikei University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colitis, Ulcerative / enzymology* Endotoxins / blood Enteral Nutrition* Food, Formulated Glutamine / administration & dosage* Guinea Pigs Intestinal Mucosa / enzymology Male Ornithine Decarboxylase / metabolism* Portal Vein Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 56-85-9/Glutamine; EC 4.1.1.17/Ornithine Decarboxylase |
| Comments/Corrections | |
Comment In:
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Br J Surg. 1995 Sep;82(9):1278-9
[PMID:
7552020
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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