Document Detail


[Efficacy of gefitinib in treatment of lung cancer patients with bone metastasis].
MedLine Citation:
PMID:  18379035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-65% of patients with metastatic lung cancer will develop bone metastasis. Bone metastases cause considerable skeletal morbidity, including bone pain, pathologic fractures, spinal cord compression and it is necessary to develop the effective treatment against bone metastasis. We reported cases of non-small-cell lung cancer who had dramatic improvements of pathologic fractures with gefitinib. In addition, gefitinib treatments elevated levels of serum Bone ALP, ICTP and ratio of Bone ALP/ICTP in patients with bone metastasis. Gefitinib may have inhibitory effects against bone resorption as well as antitumor effects.
Authors:
Yoshio Okano; Makoto Nishio
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article; Review    
Journal Detail:
Title:  Clinical calcium     Volume:  18     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-06-24     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  527-33     Citation Subset:  IM    
Affiliation:
Japanese foundation for cancer research, Cancer institute hospital, Thracic Oncology Center.
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / blood
Antineoplastic Agents / therapeutic use*
Biological Markers / blood
Bone Neoplasms / drug therapy*,  metabolism,  secondary*
Bone Resorption / diagnosis
Collagen Type I
Female
Fractures, Spontaneous / drug therapy,  etiology
Humans
Lung Neoplasms / pathology*
Middle Aged
Osteogenesis
Peptide Fragments / blood
Peptides
Procollagen / blood
Quinazolines / therapeutic use*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Biological Markers; 0/Collagen Type I; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/Quinazolines; 0/collagen type I trimeric cross-linked peptide; EC 3.1.3.1/Alkaline Phosphatase; S65743JHBS/gefitinib

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