| Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction. | |
| | |
MedLine Citation:
|
PMID: 19367054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Free radicals are important in causing neural cell injury during cerebral infarction. Although there was a randomized, placebo-controlled, double-blind study at multiple centers in Japan showing the efficacy of the free radical scavenger, edaravone, in acute cerebral infarction, to date the clinical studies are few. This study investigated the effect of edaravone on the outcome of patients with acute lacunar infarction. METHODS: We retrospectively evaluated 124 consecutive patients with first-ever acute lacunar infarctions who were admitted to our hospital within 24 hours after the onset between January 2004 and June 2007. Of these, 59 patients received both edaravone and conventional therapy (edaravone group), and the other 65 underwent conventional therapy only (non-edaravone group). There was no significant difference in patients' baseline characteristics in the two groups. The clinical outcome was assessed by the National Institutes of Health Stroke Scale (NIHSS). RESULTS: The reduction of NIHSS scale during hospitalization (1.5+/-1.0 vs. 1.0+/-1.1; p = 0.007), especially that of the motor palsy scale (1.0+/-1.0 vs. 0.5+/-1.0; p = 0.006) was significantly larger, and the percentage of patients with a favorable outcome (NIHSS at discharge < or =1) (91.5% vs. 78.5%; p = 0.044) was significantly better in the edaravone group. CONCLUSION: Edaravone improves the outcomes of patients with acute lacunar infarction, especially motor palsy, without regard to the conventional therapy performed concomitantly. |
| | |
Authors:
|
Yasuyuki Ohta; Kazuhiro Takamatsu; Tomoko Fukushima; Satomi Ikegami; Ikuko Takeda; Taisei Ota; Katsuya Goto; Koji Abe |
Related Documents
:
|
8418534 - Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. 3825494 - Is there a transitional zone between brain infarcts and the surrounding brain? a histol... 8325194 - Focal pancreatic infarction in pheochromocytoma. 3703234 - Bilateral paramedian thalamic infarctions: a ct study. 19766454 - Quantitative assessment of strain and strain rate by velocity vector imaging during dob... 21258154 - Cardiac biomarkers in the diagnosis, prognosis and management of coronary artery diseas... |
Publication Detail:
|
Type: Journal Article Date: 2009-04-15 |
Journal Detail:
|
Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-04-15 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
|
Languages: eng Pagination: 593-6 Citation Subset: IM |
Affiliation:
|
Ota Memorial Hospital, Fukuyama, Japan. yasuyuki@cc.okayama-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antipyrine / analogs & derivatives*, therapeutic use Brain Infarction / complications* Female Free Radical Scavengers / therapeutic use* Humans Male Middle Aged Paralysis / drug therapy*, etiology* Regression Analysis Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Free Radical Scavengers; 60-80-0/Antipyrine; 89-25-8/phenylmethylpyrazolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Advanced glycation end products in patients with cerebral infarction.
Next Document: Portopulmonary hypertension associated with congenital absence of the portal vein treated with bosen...