| Efficacy of flecainide in patients with supraventricular arrhythmias and respiratory insufficiency. | |
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MedLine Citation:
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PMID: 8163757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Evaluation of efficacy of intravenous flecainide to revert supraventricular arrhythmias to sinus rhythm in patients with respiratory insufficiency. DESIGN: Comparative randomized prospective trial. SETTING: ICU in a University Hospital. PATIENTS: 30 patients with acute respiratory insufficiency or acute exacerbation of chronic respiratory insufficiency and supraventricular arrhythmias. Intravenous flecainide was administered to 15 patients (Group A) (2 mg/kg for 10 min and continuous perfusion of 1.5 mg/kg for 1 h). Intravenous verapamil was administered to 15 patients (Group B) (0.15 mg/kg for 5 min and continuous perfusion of 0.005 mg/kg/min for 1 h). MEASUREMENTS AND RESULTS: The categories of patients' arrhythmias were: Group A-atrial fibrillation (AF) in 5 cases, atrial flutter (AFl) in 2, multifocal atrial tachycardia (MAT) in 4 and other supraventricular tachycardia (SVT) in 4. Group B-AF in 6 cases, AFL in 2, MAT in 2 and SVT in 5 cases. Flecainide reverted arrhythmias to sinus rhythm in 12 out of 15 cases (80%); of these 12, 11 reverted with the initial bolus. Verapamil reverted 5 out of 12 cases (33.3%, p < 0.01). No significant secondary adverse effects were detected. CONCLUSION: Intravenous flecainide is an effective antiarrhythmic drug to treat acute supraventricular arrhythmias in patients with respiratory insufficiency. |
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Authors:
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F Barranco; M Sanchez; J Rodriguez; M Guerrero |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Intensive care medicine Volume: 20 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1994 |
Date Detail:
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Created Date: 1994-05-25 Completed Date: 1994-05-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 42-4 Citation Subset: IM |
Affiliation:
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Department of Intensive Medicine, Valme Universitary Hospital, Sevilla, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Arrhythmias, Cardiac / drug therapy*, etiology Chi-Square Distribution Electrocardiography / drug effects Female Flecainide / administration & dosage, adverse effects, therapeutic use* Humans Infusions, Intravenous Lung Diseases, Obstructive / complications, drug therapy Male Middle Aged Respiratory Insufficiency / complications, drug therapy* Verapamil / administration & dosage |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil; 54143-55-4/Flecainide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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