Document Detail

Efficacy of flecainide in patients with supraventricular arrhythmias and respiratory insufficiency.
MedLine Citation:
PMID:  8163757     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Evaluation of efficacy of intravenous flecainide to revert supraventricular arrhythmias to sinus rhythm in patients with respiratory insufficiency. DESIGN: Comparative randomized prospective trial. SETTING: ICU in a University Hospital. PATIENTS: 30 patients with acute respiratory insufficiency or acute exacerbation of chronic respiratory insufficiency and supraventricular arrhythmias. Intravenous flecainide was administered to 15 patients (Group A) (2 mg/kg for 10 min and continuous perfusion of 1.5 mg/kg for 1 h). Intravenous verapamil was administered to 15 patients (Group B) (0.15 mg/kg for 5 min and continuous perfusion of 0.005 mg/kg/min for 1 h). MEASUREMENTS AND RESULTS: The categories of patients' arrhythmias were: Group A-atrial fibrillation (AF) in 5 cases, atrial flutter (AFl) in 2, multifocal atrial tachycardia (MAT) in 4 and other supraventricular tachycardia (SVT) in 4. Group B-AF in 6 cases, AFL in 2, MAT in 2 and SVT in 5 cases. Flecainide reverted arrhythmias to sinus rhythm in 12 out of 15 cases (80%); of these 12, 11 reverted with the initial bolus. Verapamil reverted 5 out of 12 cases (33.3%, p < 0.01). No significant secondary adverse effects were detected. CONCLUSION: Intravenous flecainide is an effective antiarrhythmic drug to treat acute supraventricular arrhythmias in patients with respiratory insufficiency.
F Barranco; M Sanchez; J Rodriguez; M Guerrero
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Intensive care medicine     Volume:  20     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1994  
Date Detail:
Created Date:  1994-05-25     Completed Date:  1994-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-4     Citation Subset:  IM    
Department of Intensive Medicine, Valme Universitary Hospital, Sevilla, Spain.
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MeSH Terms
Acute Disease
Aged, 80 and over
Arrhythmias, Cardiac / drug therapy*,  etiology
Chi-Square Distribution
Electrocardiography / drug effects
Flecainide / administration & dosage,  adverse effects,  therapeutic use*
Infusions, Intravenous
Lung Diseases, Obstructive / complications,  drug therapy
Middle Aged
Respiratory Insufficiency / complications,  drug therapy*
Verapamil / administration & dosage
Reg. No./Substance:
52-53-9/Verapamil; 54143-55-4/Flecainide

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