Document Detail


Efficacy of extended (six weeks) treatment with miltefosine for mucosal leishmaniasis in Bolivia.
MedLine Citation:
PMID:  19706901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether increasing the period of follow-up or increasing the duration of therapy would markedly alter the 71% cure rate of mucosal leishmaniasis in Bolivia consequent to treatment with miltefosine for 4 weeks. Increasing the follow-up from 12 months to 24 months demonstrated additional relapse in only 2 of 41 patients. Increasing the period of therapy from 4 weeks to 6 weeks only increased the cure rate to 75%. The cure rate of mucosal leishmaniasis in Bolivia, whether 4 or 6 weeks of therapy is used and whether 12 month or 24 months follow up is conducted, is approximately 70%.
Authors:
Jaime Soto; Jaime Rea; Margarita Valderrama; Julia Toledo; Luis Valda; Jaime Ardiles; Jonathan Berman
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  81     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-9     Citation Subset:  AIM; IM    
Affiliation:
Centro de Investigaciones Bioclínicas de la Fundación FADER, Bogotá, Colombia. jaime.soto@prodderma.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiprotozoal Agents / administration & dosage*,  therapeutic use*
Bolivia / epidemiology
Drug Administration Schedule
Female
Humans
Leishmaniasis, Mucocutaneous / drug therapy*,  epidemiology
Male
Phosphorylcholine / adverse effects,  analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 107-73-3/Phosphorylcholine; 58066-85-6/miltefosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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