| Efficacy of extended (six weeks) treatment with miltefosine for mucosal leishmaniasis in Bolivia. | |
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MedLine Citation:
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PMID: 19706901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether increasing the period of follow-up or increasing the duration of therapy would markedly alter the 71% cure rate of mucosal leishmaniasis in Bolivia consequent to treatment with miltefosine for 4 weeks. Increasing the follow-up from 12 months to 24 months demonstrated additional relapse in only 2 of 41 patients. Increasing the period of therapy from 4 weeks to 6 weeks only increased the cure rate to 75%. The cure rate of mucosal leishmaniasis in Bolivia, whether 4 or 6 weeks of therapy is used and whether 12 month or 24 months follow up is conducted, is approximately 70%. |
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Authors:
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Jaime Soto; Jaime Rea; Margarita Valderrama; Julia Toledo; Luis Valda; Jaime Ardiles; Jonathan Berman |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 81 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 387-9 Citation Subset: AIM; IM |
Affiliation:
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Centro de Investigaciones Bioclínicas de la Fundación FADER, Bogotá, Colombia. jaime.soto@prodderma.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiprotozoal Agents / administration & dosage*, therapeutic use* Bolivia / epidemiology Drug Administration Schedule Female Humans Leishmaniasis, Mucocutaneous / drug therapy*, epidemiology Male Phosphorylcholine / adverse effects, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 107-73-3/Phosphorylcholine; 58066-85-6/miltefosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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