Document Detail


Efficacy of erythropoietin in premature infants.
MedLine Citation:
PMID:  11938417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify the effect of early parental recombinant human erythropoietin and iron administration on the blood transfusion requirement of premature infants. METHODS: In a controlled clinical trial conducted at the neonatal intensive care unit of Al-Hada Military Hospital, Taif, Kingdom of Saudi Arabia over a 16 months period, we assigned 20 very low birth weight infants with gestational age of (mean +/- standard error of mean) 28.4 +/- 0.5 weeks and birth weight of (mean +/- standard error of mean) 1031 +/- 42 gm, to receive either intravenous recombinant human erythropoietin 200 U/kg/day and iron 1mg/kg/day or conventional therapy over a 21 day study period. Blood transfusion administration undergoes a strict protocol in our nursery. RESULTS: During the 3 week study period, the hemoglobin and hematocrit remained similar in the 2 groups while the reticulocyte counts were greater in the recombinant human erythropoietin recipients on day 14. The number and volume of blood transfusions were similar in both groups. CONCLUSION: Very low birth weight infants receive fewer blood transfusions than the number previously reported. Strict phlebotomy and transfusion criteria could minimize the need for human recombinant erythropoietin.
Authors:
Adnan A Amin; Daifulah M Alzahrani
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  23     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-08     Completed Date:  2002-06-05     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Neonatal Intensive Care Unit, Al-Hada Military Hospital, Taif, Kingdom of Saudi Arabia. adnamn@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Anemia, Neonatal / drug therapy*
Blood Transfusion
Drug Therapy, Combination
Erythropoietin, Recombinant / therapeutic use*
Female
Humans
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Infusions, Intravenous
Iron / therapeutic use
Male
Saudi Arabia
Chemical
Reg. No./Substance:
0/Erythropoietin, Recombinant; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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