Document Detail

Efficacy of eprinomectin pour-on against gastrointestinal nematode infections in sheep.
MedLine Citation:
PMID:  12591196     Owner:  NLM     Status:  MEDLINE    
Two field trials were conducted in two farms (farms A and B) in southern Italy, to assess the efficacy of eprinomectin applied topically at the dose rate of 500 micro g/kg to sheep with naturally occurring infections of gastrointestinal nematodes (GIN). The nematode population determined by necropsy consisted of Teladorsagia circumcincta, Haemonchus contortus, Trichostrongylus vitrinus, T. capricola, Nematodirus sp., and Chabertia ovina in sheep from farm A, and of T. circumcincta, T. vitrinus, T. capricola, T. colubriformis, and C. ovina in sheep from farm B. In each farm, 42 female sheep were assigned to a eprinomectin treated group (E-group) and a control untreated group (C-group) of 21 animals each. On farm A, the percentage reductions in strongyle faecal egg counts from E-group compared to C-group were 99.1% on day 10; 97.4% on day 30; and 67.0% on day 60. On farm B, on the same days, they were 95.4, 84.9, and 69.4%, respectively. In the course of the two trials, eprinomectin was well tolerated by all the animals with no adverse reactions following the topical treatment.
G Cringoli; L Rinaldi; V Veneziano; G Capelli
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Veterinary parasitology     Volume:  112     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2003-04-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Dipartimento di Patologia e Sanità Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Napoli "Federico II", Via Della Veterinaria 1, 80137, Napoli, Italy.
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MeSH Terms
Administration, Topical
Anthelmintics / administration & dosage,  adverse effects,  therapeutic use
Feces / parasitology
Intestinal Diseases, Parasitic / drug therapy,  veterinary
Ivermectin / administration & dosage*,  adverse effects,  analogs & derivatives*,  therapeutic use*
Nematoda / drug effects
Nematode Infections / drug therapy*,  veterinary*
Parasite Egg Count / veterinary
Sheep Diseases / drug therapy*,  parasitology*
Sheep, Domestic / parasitology*
Reg. No./Substance:
0/Anthelmintics; 160902-72-7/4''-epiacetylamino-4''-deoxyavermectin B1; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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