Document Detail

Efficacy of emamectin benzoate against sea lice infestations of Atlantic salmon, Salmo salar L.: evaluation in the absence of an untreated contemporary control.
MedLine Citation:
PMID:  17026671     Owner:  NLM     Status:  MEDLINE    
The efficacy of emamectin benzoate (SLICE) against sea lice infestations of Atlantic salmon, Salmo salar L., is typically assessed using untreated fish, or fish treated with alternative therapeutants, as controls. The State of Maine, USA, is currently under active management for the OIE-notifiable pathogen, infectious salmon anaemia virus (ISAV); consequently, neither control group is feasible in this region. Untreated salmon risk extensive damage from the ectoparasites, and threaten to increase vector-borne exposure or susceptibility of farms to ISAV; and the only treatment presently available in Maine is SLICE. However, because sea lice infestations are unlikely to resolve spontaneously, and response to treatment occurs within weeks, use of a pretreatment baseline is a reasonable alternative for confirmatory studies. We evaluated SLICE efficacy on Atlantic salmon farms in Cobscook Bay 2002-2005, in the absence of untreated controls, using pretreatment lice loads as a reference for calculation. Maximum efficacy ranged from 68% to 100% reduction from initial levels. Time-to-maximum efficacy ranged from 1 to 8 weeks after treatment initiation. Efficacy duration, measured between first reduction and first progressive rise in counts, ranged from 4 to 16 weeks.
L Gustafson; S Ellis; T Robinson; F Marenghi; R Endris
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of fish diseases     Volume:  29     ISSN:  0140-7775     ISO Abbreviation:  J. Fish Dis.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9881188     Medline TA:  J Fish Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  621-7     Citation Subset:  IM    
USDA APHIS VS ISA Program, Eastport, ME, USA.
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MeSH Terms
Copepoda / drug effects*
Ectoparasitic Infestations / drug therapy,  veterinary*
Fish Diseases / drug therapy*,  parasitology
Fisheries / methods
Ivermectin / analogs & derivatives*,  pharmacology,  therapeutic use
Salmo salar / parasitology*
Time Factors
Treatment Outcome
Reg. No./Substance:
137512-74-4/emamectin benzoate; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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