Document Detail

Efficacy of doxazosin in normotensive and hypertensive patients with benign prostatic hyperplasia.
MedLine Citation:
PMID:  7541549     Owner:  NLM     Status:  MEDLINE    
Benign prostatic hyperplasia (BPH) and hypertension are both common conditions in older men. It is estimated that 20 to 41% of middle-aged to elderly men may have both. Alpha-1 adrenoceptor antagonists, such doxazosin, produce significant improvements in urine flow rate and symptoms in patients with BPH. The effect of doxazosin on urine flow rate and symptoms in hypertensive men with BPH is similar to that seen in normotensive men. By contrast, doxazosin produces a significant fall in blood pressure in hypertensive men, but has minimal effect in normotensives. Doxazosin is well tolerated, irrespective of blood pressure status. Thus, it can be concluded doxazosin is an effective and well tolerated treatment for BPH which appears to have additional benefits in the management of patients with concomitant hypertension.
R S Kirby
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of urology and nephrology. Supplementum     Volume:  168     ISSN:  0300-8886     ISO Abbreviation:  Scand J Urol Nephrol Suppl     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-07     Completed Date:  1995-08-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153034     Medline TA:  Scand J Urol Nephrol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
St Bartholomew's Hospital, West Smithfield, London, UK.
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MeSH Terms
Blood Pressure / drug effects*
Doxazosin / therapeutic use*
Hypertension / complications,  physiopathology*
Middle Aged
Prostatic Hyperplasia / complications,  drug therapy*,  physiopathology
Urodynamics / drug effects
Reg. No./Substance:

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