Document Detail

Efficacy of double and triple phototherapy in term newborns with hyperbilirubinemia: the first clinical trial.
MedLine Citation:
PMID:  20025139     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Icterus is the most common medical problem in neonates and phototherapy is the standard treatment for neonatal hyperbilirubinemia. This study aimed to compare the efficacy and length of hospital stay of double and triple phototherapy in newborns with indirect hyperbilirubinemia. METHODS: In a clinical trial, 40 healthy term newborns (gestational age >37 weeks) with bilirubin > or =12 and > or =15 mg/dL in the second and third day, respectively, were randomly assigned to triple (n=20) or double phototherapy (n=20) groups. Total and direct serum bilirubin were measured at admission, 8, 16, and 24 hours after beginning of phototherapy, and every 12 hours thereafter until discharge (when bilirubin levels reached < or =10 mg/dL). RESULTS: There were 21 male (52%) and 19 female (48%) term neonates, with significant difference between patients' age, weight, and age of icterus. There was no significant difference in the rate of bilirubin decline between the two groups within the first 8, 16 and 24 hours. There was no significant difference in mean length of hospital stay between the two groups. Analysis of complications showed no difference between triple and double groups. CONCLUSION: Triple phototherapy failed to reduce total serum bilirubin and shorten length of hospitalization more rapidly than double phototherapy.
Salma Naderi; Fatemeh Safdarian; Davood Mazloomi; Elham Bushehri; Reza Hamidian
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  50     ISSN:  1875-9572     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-22     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  266-9     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Hormozgan Medical University, Hormozgan, Iran.
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MeSH Terms
Hyperbilirubinemia, Neonatal / therapy*
Infant, Newborn
Length of Stay
Phototherapy / methods*

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