Document Detail

Efficacy and distribution of single-dose preoperative antibiotic prophylaxis in high-risk gastroduodenal surgery.
MedLine Citation:
PMID:  2025800     Owner:  NLM     Status:  MEDLINE    
Although a single preoperative dose of antibiotic is now the accepted means of preventing postoperative surgical infection, the method has not been investigated adequately. In patients at high risk of infection who underwent gastroduodenal operations, the authors compared single-dose prophylaxis by intravenous cefotaxime (26 patients) with short-course perioperative prophylaxis (27 patients). No wound infection occurred, but in one patient in each group a subphrenic abscess developed after leakage at the anastomosis. The half-life of cefotaxime (1.23 +/- 0.12 hours) and its apparent volume of distribution (16.7 +/- 2.6 L/1.73 m2 resulted in perioperative levels of the antibiotic in blood (34.76 +/- 4.21 micrograms/mL), gastric mucosa (32.04 +/- 5.22 micrograms/mL) and subcutaneous fat (24.98 +/- 5.89 micrograms/mL) more than twice the usual minimal inhibitory concentration of the drug for organisms grown from the stomach contents and wound fat. These clinical and pharmacologic findings validate the efficacy of a single preoperative intravenous dose of the antibiotic in preventing postoperative infection in high-risk patients who undergo gastroduodenal surgery.
R T Lewis; R G Goodall; B Marien; M Park; W Lloyd-Smith; F M Wiegand
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  34     ISSN:  0008-428X     ISO Abbreviation:  Can J Surg     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-12     Completed Date:  1991-06-12     Revised Date:  2007-08-16    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Department of Surgery, Queen Elizabeth Hospital, Montreal, Que.
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MeSH Terms
Cefotaxime / administration & dosage*,  pharmacokinetics
Drug Administration Schedule
Gastrointestinal Diseases / surgery*
Injections, Intravenous
Middle Aged
Surgical Wound Infection / prevention & control*
Urinary Tract Infections / epidemiology,  microbiology
Reg. No./Substance:

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