| Efficacy of deoxycholate amphotericin B and unilamellar liposomal amphotericin B in prophylaxis of experimental Aspergillus fumigatus endocarditis. | |
MedLine Citation:
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PMID: 9374975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate and compare in vivo the protective efficacy of unilamellar liposomal amphotericin B (L-AmB) with that of deoxycholate amphotericin B (D-AmB) in experimental endocarditis. MATERIAL AND METHODS: In the rabbit model of experimental Aspergillus fumigatus endocarditis, two doses of each antifungal agent (1.5 mg/kg each) were administered intravenously at 4 hours and at 30 minutes before challenge with an inoculum of A. fumigatus. Three days later, the animals were sacrificed, and the aortic vegetations were analyzed. RESULTS: All 19 animals that did not receive chemoprophylaxis acquired endocarditis. In contrast, endocarditis developed in 2 of 10 animals pretreated with D-AmB (P < 0.01) and 3 of 8 animals pretreated with L-AmB (P < 0.01). Both D-AmB and L-AmB prevented the development of endocarditis due to A. fumigatus and decreased the concentration of fungi in the aortic vegetations by more than 1 log10. CONCLUSION: In the rabbit experimental model of Aspergillus endocarditis, D-AmB and L-AmB were equally effective in reducing the incidence of the infection and the tissue burden of fungi. |
Authors:
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E Mylonakis; G Chalevelakis; G Saroglou; P Danias; A D Argyropoulou; O Paniara; S A Raptis |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings Volume: 72 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-12-11 Completed Date: 1997-12-11 Revised Date: 2013-12-13 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1022-7 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
/
administration & dosage,
therapeutic use* Animals Antifungal Agents / administration & dosage, therapeutic use* Aspergillosis / microbiology*, prevention & control* Aspergillus fumigatus / drug effects* Cholagogues and Choleretics Deoxycholic Acid Disease Models, Animal Endocarditis / microbiology*, prevention & control* Liposomes Male Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Cholagogues and Choleretics; 0/Liposomes; 005990WHZZ/Deoxycholic Acid; 7XU7A7DROE/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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