Document Detail

Efficacy of denopamine, a beta 1 adrenoceptor agonist, in preventing coronary artery spasm.
MedLine Citation:
PMID:  8096549     Owner:  NLM     Status:  MEDLINE    
The selective beta 1 adrenoceptor agonist denopamine was studied for its effectiveness in abolishing active vasospastic angina in 10 patients without obstructive coronary artery stenosis. All patients had anginal attacks at least once a day during the 3-day placebo period. Denopamine, 40 mg/day, completely abolished the attacks in 7 patients (efficacy 70%). Denopamine reduced the mean daily number of anginal attacks and nitroglycerin consumption in comparison with placebo (0.56 +/- 1.23 vs 2.20 +/- 1.27; p < 0.005 and 0.10 +/- 0.24 vs 1.60 +/- 1.93; p < 0.05, respectively). Aggravation of anginal attacks was not seen in any patient. During placebo period, anginal attacks were provoked in 6 of the 10 patients who received exercise stress test, and in 6 of the 7 patients who received the cold pressor test in combination with hyperventilation. Denopamine prevented anginal attacks induced by exercise stress tests in 4 of the 6 patients (67%) and that induced by the cold pressor test in 4 of the 6 patients (67%). There were no severe adverse effects during denopamine therapy. These results suggest that 1) denopamine is a safe and effective medication for vasospastic angina; 2) beta 1 adrenoceptors may play an important role in the prevention of coronary artery spasm.
H Shimizu; J D Lee; K B Ogawa; K Shimizu; M Yamamoto; A Hara; T Nakamura
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  57     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
First Department of Internal Medicine, Fukui Medical School, Japan.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects,  therapeutic use*
Coronary Vasospasm / epidemiology,  prevention & control*
Ethanolamines / adverse effects,  therapeutic use*
Follow-Up Studies
Middle Aged
Nitroglycerin / therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Ethanolamines; 0/Placebos; 55-63-0/Nitroglycerin; 71771-90-9/denopamine

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