Document Detail

Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures.
MedLine Citation:
PMID:  9066049     Owner:  NLM     Status:  MEDLINE    
Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficacy of decoquinate against tachyzoites of N. caninum in a 5-day of treatment, cell culture flask lesion-based assay. Decoquinate killed tachyzoites at concentrations of 0.1 and 0.01 microgram ml-1. Decoquinate had little measurable effect on extracellular tachyzoites. Decoquinate acted quickly to kill intracellular stages at coccidiocidal concentrations; tachyzoites were killed within 5 min at 0.1 microgram ml-1 decoquinate.
D S Lindsay; J M Butler; B L Blagburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  68     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
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MeSH Terms
Abortion, Veterinary
Cattle Diseases
Cells, Cultured
Coccidiosis / complications,  veterinary
Coccidiostats / pharmacology*
Decoquinate / pharmacology*
Neospora / drug effects*
Pregnancy Complications, Parasitic / veterinary
Reg. No./Substance:
0/Coccidiostats; 18507-89-6/Decoquinate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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