| Efficacy of computed virtual chromoendoscopy on colorectal cancer screening: a prospective, randomized, back-to-back trial of Fuji Intelligent Color Enhancement versus conventional colonoscopy to compare adenoma miss rates. | |
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MedLine Citation:
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PMID: 20493487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Colonoscopy is the criterion standard for screening of colorectal neoplasms. Nonetheless, a substantial miss rate with conventional, white-light colonoscopy (WL) remains a challenge. OBJECTIVE: To assess whether Fuji Intelligent Color Enhancement (FICE) can detect more adenomas than WL in screening colonoscopy. DESIGN: Prospective, randomized trial of tandem colonoscopy adjusted for withdrawal time and lavage effect. SETTING: Seoul National University Hospital Healthcare System Gangnam Center, Korea. PATIENTS: This study involved 359 average-risk adults undergoing screening colonoscopy. INTERVENTION: Patients were randomized to the first withdrawal with either FICE (FICE-WL group) or WL (WL-FICE group). MAIN OUTCOME MEASUREMENTS: The primary end point measure was the difference in adenoma miss rates, and the secondary outcome measure was the adenoma detection rate. RESULTS: We enrolled 359 patients (mean age 50.6 years, male 66.9%) and randomly assigned 181 to the WL-FICE group and 178 to the FICE-WL group. The number of adenomas detected by FICE and WL was 123 and 107, respectively. The adenoma miss rate with FICE showed no significant difference compared with that of WL (6.6% vs 8.3%, P = .59). Characteristics of lesions missed by use of FICE were similar to those missed by use of WL; 93% of overall missed polyps were < or =5 mm, and none were > or =1 cm. All missed adenomas were low grade and nonpedunculated. There was no significant difference between FICE and WL in adenoma detection rate (mean 0.64 vs 0.55 per patient, P = .65) nor percentage of patients with > or =1 adenoma (33.7% vs 30.4%, P = .74). LIMITATIONS: Single-center study. CONCLUSION: FICE at screening colonoscopy did not improve the adenoma miss rate or detection rate compared with WL. |
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Authors:
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Su Jin Chung; Donghee Kim; Ji Hyun Song; Min Jung Park; Young Sun Kim; Joo Sung Kim; Hyun Chae Jung; In Sung Song |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-05-20 |
Journal Detail:
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Title: Gastrointestinal endoscopy Volume: 72 ISSN: 1097-6779 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-11-02 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
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Languages: eng Pagination: 136-42 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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diagnosis* Adult Aged Colonic Polyps / diagnosis* Colonoscopy / methods* Colorectal Neoplasms / diagnosis* Early Detection of Cancer / methods* Female Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Intestinal Mucosa / pathology Male Middle Aged Prospective Studies Republic of Korea Risk Factors Sensitivity and Specificity User-Computer Interface* Video Recording / methods* |
| Comments/Corrections | |
Comment In:
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Gastrointest Endosc. 2011 Oct;74(4):940
[PMID:
21951482
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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