Document Detail


Efficacy of computed virtual chromoendoscopy on colorectal cancer screening: a prospective, randomized, back-to-back trial of Fuji Intelligent Color Enhancement versus conventional colonoscopy to compare adenoma miss rates.
MedLine Citation:
PMID:  20493487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Colonoscopy is the criterion standard for screening of colorectal neoplasms. Nonetheless, a substantial miss rate with conventional, white-light colonoscopy (WL) remains a challenge.
OBJECTIVE: To assess whether Fuji Intelligent Color Enhancement (FICE) can detect more adenomas than WL in screening colonoscopy.
DESIGN: Prospective, randomized trial of tandem colonoscopy adjusted for withdrawal time and lavage effect.
SETTING: Seoul National University Hospital Healthcare System Gangnam Center, Korea.
PATIENTS: This study involved 359 average-risk adults undergoing screening colonoscopy.
INTERVENTION: Patients were randomized to the first withdrawal with either FICE (FICE-WL group) or WL (WL-FICE group).
MAIN OUTCOME MEASUREMENTS: The primary end point measure was the difference in adenoma miss rates, and the secondary outcome measure was the adenoma detection rate.
RESULTS: We enrolled 359 patients (mean age 50.6 years, male 66.9%) and randomly assigned 181 to the WL-FICE group and 178 to the FICE-WL group. The number of adenomas detected by FICE and WL was 123 and 107, respectively. The adenoma miss rate with FICE showed no significant difference compared with that of WL (6.6% vs 8.3%, P = .59). Characteristics of lesions missed by use of FICE were similar to those missed by use of WL; 93% of overall missed polyps were < or =5 mm, and none were > or =1 cm. All missed adenomas were low grade and nonpedunculated. There was no significant difference between FICE and WL in adenoma detection rate (mean 0.64 vs 0.55 per patient, P = .65) nor percentage of patients with > or =1 adenoma (33.7% vs 30.4%, P = .74).
LIMITATIONS: Single-center study.
CONCLUSION: FICE at screening colonoscopy did not improve the adenoma miss rate or detection rate compared with WL.
Authors:
Su Jin Chung; Donghee Kim; Ji Hyun Song; Min Jung Park; Young Sun Kim; Joo Sung Kim; Hyun Chae Jung; In Sung Song
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-05-20
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  72     ISSN:  1097-6779     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-11-02     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-42     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / diagnosis*
Adult
Aged
Colonic Polyps / diagnosis*
Colonoscopy / methods*
Colorectal Neoplasms / diagnosis*
Early Detection of Cancer / methods*
Female
Humans
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Intestinal Mucosa / pathology
Male
Middle Aged
Prospective Studies
Republic of Korea
Risk Factors
Sensitivity and Specificity
User-Computer Interface*
Video Recording / methods*
Comments/Corrections
Comment In:
Gastrointest Endosc. 2011 Oct;74(4):940   [PMID:  21951482 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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