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Efficacy of combined pegylated interferon and ribavirin therapy in Jewish patients of Israel suffering from chronic hepatitis C.
MedLine Citation:
PMID:  21553307     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The efficacy and safety of pegylated interferon and ribavirin treatment for chronic hepatitis C (CHC) in the Jewish population has not been previously ascertained. The aims of our study were to determine the efficacy of pegylated interferon and ribavirin therapy in an Israeli outpatient practice. METHODS: The medical records of 331 consecutive naïve patients with CHC infection treated with pegylated interferon and ribavirin between 2003 and 2010 were reviewed in order to document the virological response to the combination therapy. We used logistic regression to identify predictors for the sustained virological response (SVR). Variable selection in multivariable modeling was based on clinical and statistical significance and performed in a hierarchical fashion. First demographic characteristics, then patient clinical characteristics, viral characteristics, and finally adherence to the therapy were introduced into the model. RESULTS: The overall SVR was 57.1% (42.5% in genotype 1, 87.5% in genotype 2, 81.6% in genotype 3, and 100% in genotype 4). SVR was significantly associated with genotype 2 (OR 3.77, 95% CI 1.04-13.60, P = 0.04), genotype 3 (OR 9.72, 95% CI 4.07-23.20, P < 0.001), baseline viral load lower than 400,000 IU/mL (OR 23.1, 95% CI 8.23-64.98, P < 0.001), and adherence to the 80/80/80 rule (OR 36.22, 95% CI 11.14-117.72, P < 0.001). CONCLUSIONS: Combined pegylated interferon and ribavirin therapy was of similar or even higher efficacy in the Israeli population as compared to that reported by international trials in Caucasian, Hispanic, and African American populations.
Authors:
Jorge-Shmuel Delgado; Yael Baumfeld; Victor Novack; Shulamit Monitin; Alan Jotkowitz; Ohad Etzion; Alexander Fich
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-8
Journal Detail:
Title:  Hepatology international     Volume:  -     ISSN:  1936-0541     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101304009     Medline TA:  Hepatol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gastroenterology and Hepatology, Faculty of Health Sciences, The Barzilai Medical Centre, Ben-Gurion University of the Negev, Beersheba, Israel, delgado@bgu.ac.il.
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