Document Detail

Efficacy of combined modality prophylaxis including short-duration warfarin to prevent venous thromboembolism after total hip arthroplasty.
MedLine Citation:
PMID:  16781396     Owner:  NLM     Status:  MEDLINE    
This study reviewed the effectiveness of a trimodality deep venous thrombosis (DVT) prophylactic regimen after primary and revision total hip arthroplasty. Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower extremity venous ultrasonography was obtained on postoperative day 3 or 4. The incidence of asymptomatic DVT, symptomatic DVT/pulmonary embolus events within 90 days of surgery, and potential influence of risk factors was retrospectively assessed. Deep venous thrombosis incidence was 4.4% with one (0.1%) nonfatal pulmonary embolus. Increased age, male sex, and DVT history were significant risk factors for thromboembolic events within 90 days of hip arthroplasty. The combination of short-duration warfarin and mechanical prophylaxis with predischarge ultrasound screening was safe and effective in limiting the occurrence of venous thromboembolism.
James A Keeney; John C Clohisy; Madelyn C Curry; William J Maloney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of arthroplasty     Volume:  21     ISSN:  0883-5403     ISO Abbreviation:  J Arthroplasty     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703515     Medline TA:  J Arthroplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
Department of Orthopaedic Surgery, Washington University School of Medicine, 660 So. Euclid, Campus Box 8233, St. Louis, MO 63110, USA.
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MeSH Terms
Aged, 80 and over
Anticoagulants / therapeutic use*
Arthroplasty, Replacement, Hip / adverse effects*
Combined Modality Therapy
Middle Aged
Motor Activity
Postoperative Complications / prevention & control*
Regression Analysis
Retrospective Studies
Thromboembolism / prevention & control*
Treatment Outcome
Venous Thrombosis / prevention & control*
Warfarin / therapeutic use*
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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