| Efficacy of clonidine in patients with essential hypertension with neurovascular contact of the rostral ventrolateral medulla. | |
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MedLine Citation:
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PMID: 20379192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rostral ventrolateral medulla (RVLM) is an important center for regulation of sympathetic nerve activity. Several clinical studies have suggested an association between neurovascular contact (NVC) of RVLM and essential hypertension. Microvascular decompression (MVD) of RVLM decreases blood pressure (BP) in hypertensive patients with NVC of this region. Therefore, MVD could be a useful therapeutic strategy to reduce BP in these patients. However, as MVD is an invasive procedure, it is worthy to seek useful antihypertensive agents for hypertensive patients with NVC. It is reported that sympathetic nerve activity is elevated in patients with hypertension accompanied by NVC of RVLM. It is anticipated that sympatholytic agents could be effective in lowering BP in these patients. In this study, we investigated the efficacy of clonidine, an alpha2 adrenergic agonist, in essential hypertensives with NVC of RVLM. Thirty consecutive essential hypertensive patients with NVC and 30 consecutive essential hypertensive patients without contact were treated with clonidine for 4 weeks, and decreases in BP and plasma norepinephrine levels were compared between the two groups. Decreases in BP and plasma norepinephrine levels were significantly greater in patients with NVC than in those without contact. These results suggest that clonidine exhibits significantly greater reductions of BP and sympathetic nerve activity in essential hypertensive patients with NVC compared with those without contact of the rostral ventrolateral medulla. |
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Authors:
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Takao Sakuma; Satoshi Morimoto; Yasuko Aota; Nobuyuki Takahashi; Nagaoki Toyoda; Atsushi Kosaki; Minoru Maehara; Noboru Tanigawa; Koshi Ikeda; Satoshi Sawada; Toshiji Iwasaka |
Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2010-04-09 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 33 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
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Languages: eng Pagination: 633-7 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan. sakumat@hirakata.kmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects* Clonidine / therapeutic use* Female Humans Hypertension / drug therapy*, physiopathology Male Medulla Oblongata / drug effects*, physiopathology Middle Aged Norepinephrine / blood Sympathetic Nervous System / drug effects*, physiopathology Sympatholytics / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Sympatholytics; 4205-90-7/Clonidine; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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