Document Detail

Efficacy of a chlorine dioxide-containing mouthrinse in oral malodor.
MedLine Citation:
PMID:  11199703     Owner:  NLM     Status:  MEDLINE    
Studies have suggested that when chlorine dioxide is contained in a mouthrinse, it neutralizes volatile sulfur compounds in mouth air. The efficacy of a chlorine dioxide-containing mouthrinse in the reduction of oral malodor was evaluated in a randomized, controlled, double-blind, parallel group study of 31 men and women. Subjects with a maximum odor pleasantness score of < or = -1 (slightly unpleasant/stale) on a 7-point ordinal scale at both screening and baseline were randomized to treatment with the chlorine dioxide-containing rinse (n = 16) or distilled water (negative control) (n = 15). Oral malodor was evaluated at baseline (prerinse) and at 2, 4, 8, 24, 48, 72, and 96 hours postrinse by both a trained, previously calibrated panel of organoleptic judges and a factory-calibrated portable sulfide monitor. The sulfide monitor measured concentrations of volatile sulfur compounds in the subjects' mouth air 3 minutes after completion of the organoleptic assessment at each time point. The correlation between the organoleptic assessments and log-transformed sulfide monitor values was evaluated. With the chlorine dioxide mouthrinse, a statistically significant improvement in odor pleasantness, reduction in odor intensity, and reduction in oral volatile sulfur compound concentrations compared to the water control were evident at 2 hours postrinse and persisted through 8 hours postrinse. The mean (+/- SD) odor pleasantness improved from -1.25 +/- 0.31 at baseline to -0.73 +/- 0.33 at 2 hours postrinse in the chlorine dioxide group compared to -1.40 +/- 0.38 at baseline to -1.31 +/- 0.67 at 2 hours in the control group (P < 0.01). Odor pleasantness reached its maximum change from baseline to 0.63 +/- 0.45 at 8 hours postrinse. The mean (+/- SD) log-transformed sulfide monitor measurement decreased from 5.40 +/- 0.29 at baseline to 5.17 +/- 0.13 at 2 hours postrinse in the chlorine dioxide group, but increased from 5.47 +/- 0.40 at baseline to 5.56 +/- 0.54 at 2 hours in the control group (P < 0.01). As measured by the sulfide monitor, the mean volatile sulfur compound concentration in the chlorine dioxide group reached its minimum level at 8 hours postrinse (change from baseline in the log-transformed Halimeter measurement of -0.35 +/- 0.31). Thus, this study demonstrates that a one-time use of a chlorine dioxide-containing mouthrinse significantly improves mouth odor pleasantness, reduces mouth odor intensity, and reduces volatile sulfur compound concentrations in mouth air for at least 8 hours after use.
J Frascella; R D Gilbert; P Fernandez; J Hendler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)     Volume:  21     ISSN:  1548-8578     ISO Abbreviation:  Compend Contin Educ Dent     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2001-01-30     Completed Date:  2001-02-15     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9600713     Medline TA:  Compend Contin Educ Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-4, 246, 248 passim; quiz 256     Citation Subset:  D    
TKL Research, Inc., Paramus, New Jersey, USA.
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MeSH Terms
Analysis of Variance
Chlorine Compounds / therapeutic use*
Disinfectants / therapeutic use*
Double-Blind Method
Follow-Up Studies
Halitosis / metabolism,  prevention & control,  therapy*
Linear Models
Middle Aged
Mouthwashes / therapeutic use*
Oxides / therapeutic use*
Sulfur Compounds / analysis,  antagonists & inhibitors
Reg. No./Substance:
0/Chlorine Compounds; 0/Disinfectants; 0/Mouthwashes; 0/Oxides; 0/Placebos; 0/Sulfur Compounds; 10049-04-4/chlorine dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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