Document Detail

Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response.
MedLine Citation:
PMID:  22941899     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To assess the activity of ceftolozane, a novel oxyimino-cephalosporin, in comparison with ceftazidime and piperacillin/tazobactam against a multidrug-resistant Pseudomonas aeruginosa strain using a murine model of pneumonia. METHODS: Quantitative bacteriology, survival, histological examination, myeloperoxidase activity, proinflammatory cytokine levels in lungs and endothelial permeability were evaluated to determine the effects of ceftolozane and comparators on P. aeruginosa-induced pneumonia. RESULTS: After 48 h of treatment, ceftolozane reduced the bacterial load by 3-4 log(10) cfu/g of lung. Systemic dissemination of the pulmonary infection and development of lung damage were inhibited in all β-lactam-treated animals. P. aeruginosa-induced pneumonia led to elevated concentrations of tumour necrosis factor-α, interleukin (IL)-1β and macrophage inflammatory protein (MIP)-2 in the lungs. While the levels of proinflammatory cytokines decreased following ceftazidime and piperacillin/tazobactam therapy, ceftolozane exhibited increased concentrations of IL-1β and MIP-2 after 24 h of infection, resulted in significantly increased levels of recruited neutrophils within the infected lung without increasing lung endothelial permeability. CONCLUSIONS: These data strongly support ceftolozane as an effective option for the treatment of severe P. aeruginosa respiratory infections by improving the early pulmonary inflammatory response without impairing 48 h post-infection homeostasis.
Cédric Jacqueline; Antoine Roquilly; Cyndie Desessard; David Boutoille; Alexis Broquet; Virginie Le Mabecque; Gilles Amador; Gilles Potel; Jocelyne Caillon; Karim Asehnoune
Related Documents :
23974309 - Topical cidofovir for treatment of resistant viral infections.
15275609 - Chronic ascariasis and malnutrition.
25280039 - Retrospective observational study to investigate sinerga, a multifactorial nutritional ...
23095469 - Epidemic myalgia in adults associated with human parechovirus type 3 infection, yamagat...
23765259 - Methylation pattern of thbs1, gata-4, and hic1 in pediatric and adult patients infected...
23918779 - Contribution of secretory antibodies to intestinal mucosal immunity against helicobacte...
20042569 - Tlr2-dependent inflammatory response to porphyromonas gingivalis is myd88 independent, ...
21876759 - Silencing of the rotavirus nsp4 protein decreases the incidence of biliary atresia in m...
19656629 - Resistance of santa ines and crossbred ewes to naturally acquired gastrointestinal nema...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  -     ISSN:  1460-2091     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Université de Nantes, Faculté de Médecine, Thérapeutiques Cliniques et Expérimentales des Infections, EA 3826, F-44000 Nantes, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Activity of oritavancin against methicillin-resistant staphylococci, vancomycin-resistant enterococc...
Next Document:  TetAB(46), a predicted heterodimeric ABC transporter conferring tetracycline resistance in Streptoco...