Document Detail


Efficacy of botulinum toxin in chronic anal fissure.
MedLine Citation:
PMID:  16323610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic anal fissures (CAF) are caused by anal sphincter hypertonia leading to an ischaemic ulcer. By inducing temporary sphincter relaxation, botulinum toxin (Botox) injection has been shown to heal CAF in approximately 73-96% of cases in clinical trials. AIM: This study looks at the efficacy of Botox clinical practice. METHODS: The medical charts were reviewed of all patients with CAF treated with Botox (30iu injected into the sphincter complex in three 10iu aliquots) in the Ulster Hospital, Dundonald, Northern Ireland between March 1999 and November 2001. RESULTS: Fifty-one charts were identified. Four patients failed to attend for review and were excluded from the study. Of the remaining 47 patients, 37 (78.7%) were healed following Botox injection. 10 out of 37 (27.0%) developed a recurrent CAF after a median time of 16.0 months (IQR 3.8-20 months). Eight of these patients opted for repeat Botox injection, which was successful in 7 (87.5%) cases. No adverse effects were reported. CONCLUSION: Botox injection for the treatment of CAF is as effective in clinical practice as reported in clinical trials from specialist centres.
Authors:
H N Simms; K McCallion; W Wallace; W J Campbell; H Calvert; R J Moorehead
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish journal of medical science     Volume:  173     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    2004 Oct-Dec
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  188-90     Citation Subset:  IM    
Affiliation:
Department of Surgery, Ulster Hospital Trust, Dundonald, Northern Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Botulinum Toxin Type A / administration & dosage,  therapeutic use*
Female
Fissure in Ano / drug therapy*
Humans
Injections, Intramuscular
Logistic Models
Male
Middle Aged
Neuromuscular Agents / administration & dosage,  therapeutic use*
Recurrence
Treatment Outcome
Chemical
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Neuromuscular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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