Document Detail


Efficacy of beta-cyclodextrin against experimental cryptosporidiosis in neonatal lambs.
MedLine Citation:
PMID:  12053962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of beta-cyclodextrin against experimental Cryptosporidium parvum infection was evaluated in neonatal lambs. The animals were treated by oral administration of the drug at 1 g/kg of body weight during 3 consecutive days. Preventive treatment was started within 1 day of birth, and therapeutic treatment was initiated at the onset of diarrhea following confirmation of infection. Disease development and drug efficacy were evaluated by monitoring the presence or absence of diarrhea and oocyst shedding from birth until 30 days of age. Weight gains at 15 and 30 days of age were also recorded. Beta-cyclodextrin was highly effective as a prophylactic treatment; 1 animal did not acquire the infection, diarrhea was prevented in infected animals, and there was a considerable decrease in oocyst shedding. The therapeutic treatment was effective in decreasing the severity of diarrhea and the duration of oocyst shedding. The animals tolerated the drug well, and there was a significant increase in their body weights.
Authors:
J A Castro-Hermida; Y González-Losada; F Freire-Santos; M González-Warleta; M Mezo-Menéndez; E Ares-Mazás
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of parasitology     Volume:  88     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-7     Citation Subset:  IM    
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, La Coruña, España.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Coccidiostats / administration & dosage,  therapeutic use*
Cryptosporidiosis / drug therapy,  parasitology,  prevention & control,  veterinary*
Cryptosporidium parvum / drug effects*
Cyclodextrins / administration & dosage,  therapeutic use*
Female
Male
Sheep / parasitology*
Sheep Diseases / drug therapy*,  parasitology,  prevention & control*
Treatment Outcome
beta-Cyclodextrins*
Chemical
Reg. No./Substance:
0/Coccidiostats; 0/Cyclodextrins; 0/beta-Cyclodextrins; 7585-39-9/betadex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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