Document Detail


Efficacy of beta-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: a meta-analysis.
MedLine Citation:
PMID:  19418589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To systematically assess the efficacy and safety of beta-adrenergic blocker plus 5-isosorbide mononitrate (BB + ISMN) and endoscopic band ligation (EBL) on prophylaxis of esophageal variceal rebleeding.
METHODS: Randomized controlled trials (RCTs) comparing the efficacy and safety of BB + ISMN and EBL on prophylaxis of esophageal variceal rebleeding were gathered from Medline, Embase, Cochrane Controlled Trial Registry and China Biological Medicine database between January 1980 and August 2007. Data from five trials were extracted and pooled. The analyses of the available data using the Revman 4.2 software were based on the intention-to-treat principle.
RESULTS: Four RCTs met the inclusion criteria. In comparison with BB + ISMN with EBL in prophylaxis of esophageal variceal rebleeding, there was no significant difference in the rate of rebleeding [relative risk (RR), 0.79; 95% CI: 0.62-1.00; P = 0.05], bleeding-related mortality (RR, 0.76; 95% CI: 0.31-1.42; P = 0.40), overall mortality (RR, 0.81; 95% CI: 0.61-1.08; P = 0.15) and complications (RR, 1.26; 95% CI: 0.93-1.70; P = 0.13).
CONCLUSION: In the prevention of esophageal variceal rebleeding, BB + ISMN are as effective as EBL. There are few complications with the two treatment modalities. Both BB + ISMN and EBL would be considered as the first-line therapy in the prevention of esophageal variceal rebleeding.
Authors:
Shi-Hua Ding; Jun Liu; Jian-Ping Wang
Related Documents :
7027499 - Hemostatic suture of the stomach for the treatment of massive hemorrhage due to esophag...
17252459 - Risk factors for local recurrence of superficial esophageal cancer after treatment by e...
3486489 - Two-year experience of management of bleeding esophageal varices with a coordinated tre...
15750449 - Chronic transfusion therapy for children with sickle cell disease and recurrent acute c...
15949959 - New approaches to the treatment of congenital vascular malformations (cvms)--a single c...
9922309 - Oral budesonide for prevention of postsurgical recurrence in crohn's disease. the ioibd...
25099819 - Predicting a successful ureteral access sheath insertion: a bi-center prospective study.
8336609 - Transcatheter radiofrequency ablation. early experience with supraventricular tachyarrh...
7506239 - The use of intermittent chlorhexidine bladder irrigation in the prevention of post-pros...
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-07-28     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2151-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Endoscopy*
Esophageal and Gastric Varices / etiology,  prevention & control*,  therapy
Humans
Isosorbide Dinitrate / analogs & derivatives*,  therapeutic use
Ligation*
Liver Cirrhosis / complications
Randomized Controlled Trials as Topic
Treatment Outcome
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents; 16051-77-7/isosorbide-5-mononitrate; IA7306519N/Isosorbide Dinitrate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 e...
Next Document:  Unusual presentations of eosinophilic gastroenteritis: case series and review of literature.