Document Detail

Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders.
MedLine Citation:
PMID:  18533765     Owner:  NLM     Status:  MEDLINE    
Early-onset psychotic illnesses in children and adolescents are not as rare as is commonly believed. These disorders, which include schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, and major depression with psychotic features, often have a chronic and severe course and poor long-term outcome. Many patients with early-onset schizophrenia have greater functional impairments than most patients with adult-onset schizophrenia. Magnetic resonance imaging studies show that patients with early-onset schizophrenia experience substantial gray matter loss during adolescence, which is not observed in studies of patients with adult-onset schizophrenia. The chronic course, severe functional impairments, and poor prognosis of early-onset psychosis create a great need to identify effective and safe treatments for youth with psychosis. Although atypical anti-psychotics have been considered superior to traditional antipsychotics, there has been little controlled information to inform clinical decisions until recently. Over the past 5 years, several studies have been initiated to address these questions. The results of the studies completed to date are reviewed.
Linmarie Sikich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  69 Suppl 4     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-06     Completed Date:  2008-07-09     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7160, USA.
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MeSH Terms
Age of Onset
Antipsychotic Agents / therapeutic use*
Benzodiazepines / therapeutic use
Brain Diseases / diagnosis,  epidemiology
Chronic Disease
Clozapine / therapeutic use
Disease Progression
Magnetic Resonance Imaging
Piperazines / therapeutic use
Psychotic Disorders / diagnosis,  drug therapy*,  epidemiology
Quinolones / therapeutic use
Schizophrenia / diagnosis,  drug therapy*,  epidemiology
Thiazoles / therapeutic use
Treatment Failure
Reg. No./Substance:
0/Antipsychotic Agents; 0/Piperazines; 0/Quinolones; 0/Thiazoles; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 5786-21-0/Clozapine; 6UKA5VEJ6X/ziprasidone; 82VFR53I78/aripiprazole

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