| Efficacy of anti-TNF in Crohn's disease: how does it work? | |
| | |
MedLine Citation:
|
PMID: 19916961 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Several TNF antagonists, mainly monoclonal antibodies, have shown to be efficacious in the therapy of Crohn's disease. Despite the fact that they have been used for over a decade, their precise mechanism of action is still a matter of investigation. The effects of anti-TNF agents are mediated by multiple mechanisms including direct neutralization of soluble TNF and interaction with membrane-bound TNF. Anti-TNF agents may act by reduction of proinflammatory cytokine levels, elimination or clearance of active inflammatory cells from inflamed tissue which can conceptually be achieved by a number of mechanisms including apoptosis induction, antibody and complement mediated cytotoxicity and inhibition of cell migration into the intestinal tissue. Regulatory events both in the cellular and intracellular levels probably play a role as well. Finally, effects of anti-TNF agents may vary according to their physical contact with TNF leading to different binding avidities, conformational changes and variable downstream effects. These effects may also be influenced by structural differences in the non-TNF binding domain which affects the ability of each drug to interact with the immune system. Our understanding of these mechanisms of action is limited by the fact that much of the data was obtained using artificial in vitro systems of which their relevance to the in vivo situation is uncertain. |
| | |
Authors:
|
Yehuda Chowers; Matthieu Allez |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2009-11-17 |
Journal Detail:
|
Title: Current drug targets Volume: - ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Gastroenterology, Rambam Health Care Campus, Haifa, Bat Galim, Israel. ychowers@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-TNF AND Crohn's Disease: When Should We Start?
Next Document: Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases ap...