Document Detail

Efficacy of alpha,beta-arteether in acute uncomplicated P. falciparum malaria.
MedLine Citation:
PMID:  9403348     Owner:  NLM     Status:  MEDLINE    
A phase-III clinical trial was conducted in 50 patients (42M + 8F) with acute uncomplicated falciparum malaria from Delhi during the period of September to November 1995. Their mean age was 27.2 years, and the mean parasitaemia on day 0 was 0.65%. Patients were hospitalized and treated with a new ethyl derivative of artemisinin developed at CDRI called alpha, beta-arteether, at the dosage of 150 mg l/M for three consecutive days. Peripheral smears were examined every day for 4 days and then weekly up to 28 days. The results of the study showed that the mean parasite and fever clearance times were respectively 19.94 +/- 6.87 and 37.81 +/- 21.67 hours. Within 48 h, 70% of the cases became afebrile and the peripheral smear was negative in 100% of the cases. The drug was well tolerated. Three cases (6%) had recrudescence within 28 days. It is concluded that alpha, beta-arteether is a safe, effective and rapidly acting antimalarial.
N Valecha; S Gupta; D Usha; S Biswas; A Sharma; T Adak; O P Asthana; V P Sharma
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  17     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
Malaria Research Centre, Delhi, India.
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MeSH Terms
Antimalarials / adverse effects,  immunology,  therapeutic use*
Immunoenzyme Techniques
Immunoglobulin G / immunology
Malaria, Falciparum / drug therapy*,  immunology
Middle Aged
Plasmodium falciparum / immunology
Sesquiterpenes / adverse effects,  immunology,  therapeutic use*
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Immunoglobulin G; 0/Sesquiterpenes; 109716-83-8/arteether

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