Document Detail

Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study.
MedLine Citation:
PMID:  18976257     Owner:  NLM     Status:  In-Process    
To study the efficacy of alpha lipoic acid (ALA) in a group of patients with burning mouth syndrome (BMS). Sixty BMS patients, 30 treated with ALA (Thioderm) 800 mg day(-1) for 8 weeks and 30 patients on the same protocol with a placebo. The symptomatology was measured on a Visual Analogue Scale (VAS). Sixty patients (54 females and 6 males, mean age 64.37 +/- 11.61 years) were included. Thirty-nine patients completed the treatment (23 with ALA and 16 with a placebo). Reviews were carried out at 0, 1 and 2 months. No statistically significant differences were found in the average pre- and post-treatment values for pain with the VAS scores, obtained in the placebo (6.6 +/- 2.5 - 2.8 +/- 25 = 3.8 +/- 3.7) versus ALA (6.3 +/- 2.8 - 4.0 +/- 2.7 = 2.2 +/- 2.6). Only one patient pertaining to the group treated with ALA abandoned because of adverse gastrointestinal side effects. The results showed no significant differences between the two groups.
P López-Jornet; F Camacho-Alonso; S Leon-Espinosa
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Publication Detail:
Type:  Journal Article     Date:  2008-10-18
Journal Detail:
Title:  Journal of oral rehabilitation     Volume:  36     ISSN:  1365-2842     ISO Abbreviation:  J Oral Rehabil     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0433604     Medline TA:  J Oral Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-7     Citation Subset:  D; IM    
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
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