| Efficacy and adverse effects of the coronary active perfusion system--from a viewpoint of perfusional timing. | |
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MedLine Citation:
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PMID: 12732089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We developed a coronary active perfusion system (CAPS) to avoid myocardial ischemia during off-pump coronary artery bypass (OPCAB). The purpose of this study was to determine the optimal timing of CAPS perfusion, and to investigate any adverse effects when it is driven within the systolic phase. Twenty-four pigs were divided into four groups: (A) systolic, (B) early-diastolic, (C) middle-diastolic, and (D) late-diastolic perfusion. Myocardial blood flow (MBF), hemodynamic and mechanical data were measured during 30 minutes of CAPS perfusion. MBF in group A was lower than in the other groups (p<0.001), but no significant differences were observed among groups B to D. End-systolic pressure-volume relation (Mw) and preload recruitable stroke work relation (Ees) in group A was lower than in groups B to D (p<0.01 and p<0.05, respectively), but no significant differences were observed among groups B to D. CAPS could maintain regional MBF and left ventricular function if it was driven only within the diastolic phase and required no strict adjustment, but CAPS has an adverse effect when it is driven in the systolic phase. |
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Authors:
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Hiroyuki Kamiya; Go Watanabe; Toshio Doi; Taro Saito; Masao Takahashi; Shigeyuki Tomita; Toshihide Tsukioka; Taro Kanamori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Volume: 9 ISSN: 1341-1098 ISO Abbreviation: Ann Thorac Cardiovasc Surg Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-06 Completed Date: 2003-08-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9703158 Medline TA: Ann Thorac Cardiovasc Surg Country: Japan |
Other Details:
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Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
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Department of Surgery I, Kanazawa University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiac Output Coronary Artery Bypass* / instrumentation, methods Coronary Circulation* Heart Rate Heart Ventricles / pathology Infusion Pumps* Pulsatile Flow Swine Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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