| Efficacy and tolerability of split-dose magnesium citrate: low-volume (2 liters) polyethylene glycol vs. single- or split-dose polyethylene glycol bowel preparation for morning colonoscopy. | |
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MedLine Citation:
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PMID: 20485282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance of a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen for morning colonoscopy. METHODS: A total of 232 patients were randomly assigned to receive 4 liters PEG (day before procedure; group 1, n=79), 2 liters PEG (day before procedure) followed by another 2 liters PEG (day of procedure; group 2, n=80), or magnesium citrate (250 ml, day before procedure) followed by 2 liters PEG (day of procedure; group 3, n=73). The quality of bowel cleansing, tolerability, and adverse effects in group 3 were compared with those in groups 1 and 2. RESULTS: Satisfactory bowel preparation was more frequently reported for group 3 than for group 1 (75% vs. 51%, P=0.001) and was similar to that for group 2 (75% vs. 76%, P=0.896). A significantly greater proportion of patients in group 3 graded their overall satisfaction as satisfactory compared with group 1 (43% vs. 23%, P=0.010), and the proportion was similar to that in group 2 (43% vs. 35%, P=0.133). Patients in group 3 were more willing to repeat the same preparation regimen, if necessary, than those in group 1 (93% vs. 48%, P<0.001) or group 2 (93% vs. 62%, P<0.001). CONCLUSIONS: The split-dose magnesium citrate-low-volume (2 liters) PEG regimen was more efficient than and preferred to the conventional regimen of 4 liters of PEG, and it was equally efficient as, but, again, preferred to the split-dose (2+2 liters) regimen for morning colonoscopy. |
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Authors:
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Sin Sil Park; Dong Hyun Sinn; Young-Ho Kim; Yeun Jung Lim; Yang Sun; Jun Haeng Lee; Jin Yong Kim; Dong Kyung Chang; Hee Jung Son; Poong-Lyul Rhee; Jong Chul Rhee; Jae J Kim |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-05-18 |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 105 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-07-15 Revised Date: 2011-02-02 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 1319-26 Citation Subset: IM |
Affiliation:
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Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cathartics / administration & dosage* Citric Acid / administration & dosage* Colonoscopy* Drug Administration Schedule Female Humans Male Middle Aged Organometallic Compounds / administration & dosage* Patient Acceptance of Health Care Polyethylene Glycols / administration & dosage* Prospective Studies Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Cathartics; 0/Organometallic Compounds; 0/Polyethylene Glycols; 0/magnesium citrate; 77-92-9/Citric Acid |
| Comments/Corrections | |
Comment In:
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Endoscopy. 2011 Jan;43(1):63-6
[PMID:
21234844
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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