Document Detail

Efficacy and tolerability of split-dose magnesium citrate: low-volume (2 liters) polyethylene glycol vs. single- or split-dose polyethylene glycol bowel preparation for morning colonoscopy.
MedLine Citation:
PMID:  20485282     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance of a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen for morning colonoscopy.
METHODS: A total of 232 patients were randomly assigned to receive 4 liters PEG (day before procedure; group 1, n=79), 2 liters PEG (day before procedure) followed by another 2 liters PEG (day of procedure; group 2, n=80), or magnesium citrate (250 ml, day before procedure) followed by 2 liters PEG (day of procedure; group 3, n=73). The quality of bowel cleansing, tolerability, and adverse effects in group 3 were compared with those in groups 1 and 2.
RESULTS: Satisfactory bowel preparation was more frequently reported for group 3 than for group 1 (75% vs. 51%, P=0.001) and was similar to that for group 2 (75% vs. 76%, P=0.896). A significantly greater proportion of patients in group 3 graded their overall satisfaction as satisfactory compared with group 1 (43% vs. 23%, P=0.010), and the proportion was similar to that in group 2 (43% vs. 35%, P=0.133). Patients in group 3 were more willing to repeat the same preparation regimen, if necessary, than those in group 1 (93% vs. 48%, P<0.001) or group 2 (93% vs. 62%, P<0.001).
CONCLUSIONS: The split-dose magnesium citrate-low-volume (2 liters) PEG regimen was more efficient than and preferred to the conventional regimen of 4 liters of PEG, and it was equally efficient as, but, again, preferred to the split-dose (2+2 liters) regimen for morning colonoscopy.
Sin Sil Park; Dong Hyun Sinn; Young-Ho Kim; Yeun Jung Lim; Yang Sun; Jun Haeng Lee; Jin Yong Kim; Dong Kyung Chang; Hee Jung Son; Poong-Lyul Rhee; Jong Chul Rhee; Jae J Kim
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-05-18
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  105     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-07-15     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1319-26     Citation Subset:  IM    
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Cathartics / administration & dosage*
Citric Acid / administration & dosage*
Drug Administration Schedule
Middle Aged
Organometallic Compounds / administration & dosage*
Patient Acceptance of Health Care
Polyethylene Glycols / administration & dosage*
Prospective Studies
Single-Blind Method
Reg. No./Substance:
0/Cathartics; 0/Organometallic Compounds; 0/Polyethylene Glycols; 0/magnesium citrate; 77-92-9/Citric Acid
Comment In:
Endoscopy. 2011 Jan;43(1):63-6   [PMID:  21234844 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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