Document Detail


The efficacy of terlipressin versus adrenaline in swine cardiopulmonary resuscitation.
MedLine Citation:
PMID:  22063374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the efficacy of terlipressin (TP) vs. adrenaline (ADR) in increasing coronary perfusion pressure (CPP) and return of spontaneous circulation (ROSC) in swine CPR.
METHODS: Under anesthesia with ketamine/thiopental, ventricular fibrillation was induced in 44 female immature pigs, remaining unassisted for 10 minutes, followed by 2 minutes of manual CPR (100 compression/10 ventilations/min with air). Animals were, then, divided into four groups: 1) ADR (45μg.kg(-1)); 2) saline-placebo (10mL); 3) TP 20μg.kg(-1)); and TP (20μg.kg(-1)) + ADR (45μg.kg(-1)). Defibrillation was performed after 2 minutes, observing surviving animals for a 30-minute period. Electrocardiogram, systemic BP, DBP, and PetCO(2) were monitored continuously.
RESULTS: Terlipressin did not differ from placebo regarding the effects on CPP, with low rates of ROSC in both groups (1/11 vs. 2/11; p=NS). Adrenaline increased CPP from 13±12 to 54±15mmHg (p<0.0001), similar effect to TP + ADR (from 21±10 to 45±13mmHg; p<0.0001), with high rates of ROSC/survivors in both groups (10/11 vs. 9/11, respectively). Among survivors, greater MAP was observed in the TP + ADR group vs. ADR (105±19mmHg vs. 76±21mmHg; p=0.0157) groups.
CONCLUSIONS: Adrenaline and TP + ADR were effective on maintaining CPP/ROSC in this experimental model, but isolated TP did not differ from placebo. However, in surviving animals in the TP + ADR group, greater hemodynamic stability was observed after ROSC, suggesting that TP can be a useful medication in the management of post-CPR hypotension.
Authors:
Carlos Cezar Ivo Sant'ana Ovalle; Marcos Mello Moreira; Luiz Claudio Martins; Sebastião Araujo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  61     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-11-08     Completed Date:  2012-03-27     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; mul     Pagination:  728-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Editora Ltda. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / therapeutic use*
Animals
Cardiopulmonary Resuscitation*
Coronary Circulation / drug effects*
Epinephrine / therapeutic use*
Female
Lypressin / analogs & derivatives*,  therapeutic use
Swine
Ventricular Fibrillation / therapy*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 14636-12-5/terlipressin; 50-57-7/Lypressin; YKH834O4BH/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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