Document Detail

The efficacy of terlipressin versus adrenaline in swine cardiopulmonary resuscitation.
MedLine Citation:
PMID:  22063374     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the efficacy of terlipressin (TP) vs. adrenaline (ADR) in increasing coronary perfusion pressure (CPP) and return of spontaneous circulation (ROSC) in swine CPR.
METHODS: Under anesthesia with ketamine/thiopental, ventricular fibrillation was induced in 44 female immature pigs, remaining unassisted for 10 minutes, followed by 2 minutes of manual CPR (100 compression/10 ventilations/min with air). Animals were, then, divided into four groups: 1) ADR (45μ; 2) saline-placebo (10mL); 3) TP 20μ; and TP (20μ + ADR (45μ Defibrillation was performed after 2 minutes, observing surviving animals for a 30-minute period. Electrocardiogram, systemic BP, DBP, and PetCO(2) were monitored continuously.
RESULTS: Terlipressin did not differ from placebo regarding the effects on CPP, with low rates of ROSC in both groups (1/11 vs. 2/11; p=NS). Adrenaline increased CPP from 13±12 to 54±15mmHg (p<0.0001), similar effect to TP + ADR (from 21±10 to 45±13mmHg; p<0.0001), with high rates of ROSC/survivors in both groups (10/11 vs. 9/11, respectively). Among survivors, greater MAP was observed in the TP + ADR group vs. ADR (105±19mmHg vs. 76±21mmHg; p=0.0157) groups.
CONCLUSIONS: Adrenaline and TP + ADR were effective on maintaining CPP/ROSC in this experimental model, but isolated TP did not differ from placebo. However, in surviving animals in the TP + ADR group, greater hemodynamic stability was observed after ROSC, suggesting that TP can be a useful medication in the management of post-CPR hypotension.
Carlos Cezar Ivo Sant'ana Ovalle; Marcos Mello Moreira; Luiz Claudio Martins; Sebastião Araujo
Related Documents :
17471094 - Serial arterial embolization for large sacral giant-cell tumors: mid- to long-term resu...
9205224 - Renal angiomyolipoma: selective arterial embolization--effectiveness and changes in ang...
21917614 - In vivo vascularity alterations in repaired rotator cuffs determined by contrast-enhanc...
7815144 - Linear accelerator radiosurgery for arteriovenous malformations: the relationship of si...
20505814 - Conscious sedation and emergency department length of stay: a comparison of propofol, k...
21954764 - Progressive correction of severe spinal deformities with halo-gravity traction.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  61     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-11-08     Completed Date:  2012-03-27     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; mul     Pagination:  728-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Editora Ltda. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Agonists / therapeutic use*
Cardiopulmonary Resuscitation*
Coronary Circulation / drug effects*
Epinephrine / therapeutic use*
Lypressin / analogs & derivatives*,  therapeutic use
Ventricular Fibrillation / therapy*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 14636-12-5/terlipressin; 50-57-7/Lypressin; YKH834O4BH/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  What do patients know about the work of anesthesiologists?
Next Document:  Assessing the use of 50% enantiomeric excess bupivacaine-loaded microspheres after sciatic nerve blo...