Document Detail

Efficacy of suprachoroidal-transretinal stimulation in a rabbit model of retinal degeneration.
MedLine Citation:
PMID:  19933186     Owner:  NLM     Status:  MEDLINE    
Purpose. To develop a middle-sized animal model of outer retinal degeneration and to evaluate the effectiveness of suprachoroidal-transretinal stimulation (STS) in eliciting cortical potentials from this model. Methods. Twelve rabbits were intravenously injected with 0.47 mg/kg verteporfin and the retinas were irradiated with a red light for 90 minutes. Fluorescein angiography and full-field and focal electroretinography (ERG) were performed at 7 and 28 days after the irradiation. Electrically evoked potentials (EEPs) were elicited by electrical stimulation, with the STS electrode implanted over the irradiated region, 1 month and 1 year after the irradiation. EEPs were also recorded from three rabbits before and after retinotomy of the normal retina surrounding the degenerated area, to eliminate the influence of stray currents. The retina beneath the site of the STS electrode was examined histologically at 1 month (group 1) and 1 year (group 2) after the irradiation. Results. An extensive area of degeneration was detected histologically, mainly in the outer retina after the irradiation. Focal ERGs were not recorded when the stimulus was confined to the irradiated area; however, EEPs were successfully elicited by STS of the same area 1 month and 1 year after the irradiation. The 360 degrees retinectomy did not significantly alter the amplitudes, the implicit times, or the thresholds of EEPs evoked by STS. Conclusions. Verteporfin with light irradiation induces degeneration predominantly in the outer retinal layers in rabbits. The elicitation of EEPs by STS from the degenerated area suggests that the STS system may be useful in patients with retinitis pigmentosa.
Kentaro Nishida; Motohiro Kamei; Mineo Kondo; Hirokazu Sakaguchi; Mihoko Suzuki; Takashi Fujikado; Yasuo Tano
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Publication Detail:
Type:  Journal Article     Date:  2009-11-20
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  51     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2263-8     Citation Subset:  IM    
Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
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MeSH Terms
Choroid / physiology*
Disease Models, Animal*
Electric Stimulation
Electrodes, Implanted
Evoked Potentials, Visual / physiology*
Fluorescein Angiography
Photic Stimulation
Photochemotherapy / adverse effects
Photosensitizing Agents / toxicity
Porphyrins / toxicity
Retina / physiology*
Retinal Degeneration / chemically induced,  physiopathology*
Reg. No./Substance:
0/Photosensitizing Agents; 0/Porphyrins; 129497-78-5/verteporfin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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