| Efficacy of Subgingivally Delivered Simvastatin in the Treatment of Type 2 Diabetes Subjects With Chronic Periodontitis: A Randomized Double Blinded Controlled Clinical Trial. | |
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MedLine Citation:
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PMID: 22420871 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, it has been reported that statins promote bone formation. The present study was designed to investigate the effectiveness of SMV, 1.2 % in an indigenously prepared biodegradable controlled-release gel as, as an adjunct to scaling and root planing (SRP) in the treatment of type 2 diabetes subjects with chronic periodontitis. Methods: Thirty eight patients were categorized into two treatment groups: SRP plus SMV, 1.2 % and SRP plus placebo. Clinical parameters were recorded at baseline before SRP and at 3, 6 and 9 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL). At baseline, after 6 months and 9 months, radiologic assessment of intrabony defect (IBD) fill was done using computer-aided software. Results: Mean probing depth reduction and mean clinical attachment level gain was found to greater in SMV group than placebo group, at 3, 6 and 9 months. Furthermore, significantly greater mean percentage of bone fill was found in the SMV group (32.64 ± 12.90%) compared to placebo group (4.22 ± 9.75%). Conclusion: There was a greater decrease in mSBI and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in type 2 diabetes subjects with chronic periodontitis. |
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Authors:
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A R Pradeep; Nishanth S Rao; Pavan Bajaj; Minal Kumari |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-16 |
Journal Detail:
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Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dept of Periodontics, Govt. Dental College & Research Institute, Bangalore 560002. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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