| Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study. | |
| | |
MedLine Citation:
|
PMID: 19837428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We investigated the effect of the new sympathetic alpha1A-adrenoceptor antagonist silodosin for relieving benign prostatic obstruction by pressure flow study. MATERIALS AND METHODS: In this open, nonblinded, prospective study we administered 8 mg silodosin daily for 4 weeks in 60 patients with lower urinary tract symptoms associated with benign prostatic enlargement. As a primary outcome measure, we assessed changes in bladder function and benign prostatic obstruction using pressure flow study. As secondary outcome measures, changes in subjective symptoms and quality of life were assessed by the International Prostate Symptom Score. Objective changes in urination status were also assessed by free uroflowmetry in terms of maximum flow rate and post-void residual urine volume. RESULTS: A total of 57 patients were enrolled for analysis. In the storage phase of the pressure flow study bladder capacity at first desire to void increased significantly with no significant change in maximum cystometric capacity. Of 24 patients 14 (58.3%) with uninhibited detrusor contractions before administration showed apparent improvement in detrusor overactivity after administration, including 6 in whom uninhibited contractions disappeared. In the voiding phase mean detrusor pressure at maximum flow significantly decreased from 72.5 to 51.4 cm H(2)O. The mean bladder outlet obstruction index decreased significantly from 60.6 to 33.8. Obstruction grade assessed by the Schaefer nomogram improved in all except 1 patient. Total symptom and quality of life scores, maximum flow rate and post-void residual urine volume on free uroflowmetry significantly improved. CONCLUSIONS: Silodosin improved lower urinary tract symptoms by improving bladder storage function and relieving benign prostatic obstruction. |
| | |
Authors:
|
Yoshihisa Matsukawa; Momokazu Gotoh; Tomonori Komatsu; Yasuhito Funahashi; Naoto Sassa; Ryohei Hattori |
Related Documents
:
|
1142498 - Acute renal insufficiency following hydrostatic pressure treatment: comments on technic... 8098548 - The influence of beta-adrenoceptor and muscarinic receptor agonists and antagonists on ... 82998 - Intravesical pressure during transurethral resection using iglesias resectoscope with c... 19104508 - The use of one-channel water cystometry in patients with a spinal cord lesion: practica... 7019368 - Effect of 12-hour infusions of saralasin or captopril on blood pressure in hypertensive... 1142498 - Acute renal insufficiency following hydrostatic pressure treatment: comments on technic... |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2009-10-17 |
Journal Detail:
|
Title: The Journal of urology Volume: 182 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-12 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 2831-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan. yoshi44@med.nagoya-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Humans Indoles / therapeutic use* Male Middle Aged Pressure Prospective Studies Prostatic Hyperplasia / complications*, drug therapy*, physiopathology Prostatism / drug therapy*, etiology*, physiopathology Urinary Bladder Neck Obstruction / drug therapy*, etiology*, physiopathology Urodynamics |
| Chemical | |
Reg. No./Substance:
|
0/Indoles; 0/KMD 3213 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cost-Effectiveness of Sacral Neuromodulation Versus Intravesical Botulinum A Toxin for Treatment of ...
Next Document: Intravesical prostatic protrusion in men in Olmsted County, Minnesota.