Document Detail

Efficacy of silicate-substituted calcium phosphate ceramic in posterolateral instrumented lumbar fusion.
MedLine Citation:
PMID:  20479699     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN/SETTING: Retrospective review of a consecutive, nonrandomized series operated on by 2 surgeons.
OBJECTIVE: To evaluate the clinical and radiographic effectiveness of a silicated hydroxyapatite ceramic as a bone graft substitute in a series of patients undergoing posterolateral instrumented lumbar fusion.
SUMMARY OF BACKGROUND DATA: Newer-generation synthetic ceramics have been refined to maximize their host-graft interaction and stimulation of new tissue formation, including silicate-substitution.
METHODS: An independent radiologist interpreted the computed tomography images at 6, 12, and 24 months after surgery. Forty-two patients with 1- or 2-level lumbar degenerative disorders underwent posterior laminectomy (when indicated) and posterolateral fusion with instrumentation. Surgical levels included 15 patients who underwent 2-level and 27 single-level fusion procedures (57 levels operated on in total).
RESULTS: The average back pain scores improved from 5.6 ± 2.5 preoperative to 2.1 ± 2.5 at follow-up (P < 0.05). Similar results were seen with leg pain improvement from 5.8 ± 2.5 to 1.4 ± 1.9 (P < 0.05). At 6 months, 35% of levels revealed fusion, which increased to 76.2% and 76.5% at 12 and 24 months, respectively. No evidence of ectopic bone formation or osteolysis was noted.
CONCLUSION: In this study, a silicated calcium phosphate-based ceramic has been shown to be effective as a graft substitute and eliminate the need for autogenous iliac crest bone graft. The results confirm radiographic healing in posterolateral instrumented lumbar fusion at 24-months follow-up. The clinical outcomes also substantiate significant pain improvement consistent with published data in the literature compared with other bone graft alternatives.
Louis G Jenis; Robert J Banco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Spine     Volume:  35     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-18     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1058-63     Citation Subset:  IM    
Boston Spine Group, Newton, MA, USA.
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MeSH Terms
Aged, 80 and over
Calcium Phosphates / therapeutic use*
Ceramics / therapeutic use*
Durapatite / therapeutic use
Follow-Up Studies
Lumbar Vertebrae / radiography,  surgery*
Middle Aged
Pain / epidemiology
Prospective Studies
Retrospective Studies
Silicates / therapeutic use*
Spinal Fusion / methods*
Treatment Outcome
Reg. No./Substance:
0/Calcium Phosphates; 0/Ceramics; 0/Silicates; 1306-06-5/Durapatite; 97Z1WI3NDX/calcium phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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