| Efficacy of silicate-substituted calcium phosphate ceramic in posterolateral instrumented lumbar fusion. | |
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MedLine Citation:
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PMID: 20479699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY DESIGN/SETTING: Retrospective review of a consecutive, nonrandomized series operated on by 2 surgeons. OBJECTIVE: To evaluate the clinical and radiographic effectiveness of a silicated hydroxyapatite ceramic as a bone graft substitute in a series of patients undergoing posterolateral instrumented lumbar fusion. SUMMARY OF BACKGROUND DATA: Newer-generation synthetic ceramics have been refined to maximize their host-graft interaction and stimulation of new tissue formation, including silicate-substitution. METHODS: An independent radiologist interpreted the computed tomography images at 6, 12, and 24 months after surgery. Forty-two patients with 1- or 2-level lumbar degenerative disorders underwent posterior laminectomy (when indicated) and posterolateral fusion with instrumentation. Surgical levels included 15 patients who underwent 2-level and 27 single-level fusion procedures (57 levels operated on in total). RESULTS: The average back pain scores improved from 5.6 ± 2.5 preoperative to 2.1 ± 2.5 at follow-up (P < 0.05). Similar results were seen with leg pain improvement from 5.8 ± 2.5 to 1.4 ± 1.9 (P < 0.05). At 6 months, 35% of levels revealed fusion, which increased to 76.2% and 76.5% at 12 and 24 months, respectively. No evidence of ectopic bone formation or osteolysis was noted. CONCLUSION: In this study, a silicated calcium phosphate-based ceramic has been shown to be effective as a graft substitute and eliminate the need for autogenous iliac crest bone graft. The results confirm radiographic healing in posterolateral instrumented lumbar fusion at 24-months follow-up. The clinical outcomes also substantiate significant pain improvement consistent with published data in the literature compared with other bone graft alternatives. |
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Authors:
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Louis G Jenis; Robert J Banco |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Spine Volume: 35 ISSN: 1528-1159 ISO Abbreviation: Spine Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-18 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: United States |
Other Details:
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Languages: eng Pagination: E1058-63 Citation Subset: IM |
Affiliation:
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Boston Spine Group, Newton, MA, USA. ljenis@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Calcium Phosphates / therapeutic use* Ceramics / therapeutic use* Durapatite / therapeutic use Female Follow-Up Studies Humans Incidence Lumbar Vertebrae / radiography, surgery* Male Middle Aged Osteogenesis Osteolysis Pain / epidemiology Prospective Studies Retrospective Studies Silicates / therapeutic use* Spinal Fusion / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Calcium Phosphates; 0/Ceramics; 0/Silicates; 1306-06-5/Durapatite; 97Z1WI3NDX/calcium phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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