Document Detail

Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
MedLine Citation:
PMID:  21094951     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare oral ibuprofen with intravenous ibuprofen for closure of patent ductus arteriosus in very low birth weight (VLBW) preterm infants.
STUDY DESIGN: In a prospective, randomized study, 102 VLBW preterm infants with patent ductus arteriosus received either intravenous or oral ibuprofen at an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 hours. The success rate and evaluation of renal tolerance using cystatin-C were the major outcomes.
RESULTS: Patent ductus arteriosus closure rate was significantly higher with oral ibuprofen (84.6% versus 62%) after the first course of the treatment (P = .011). The cystatin-C level increased significantly after treatment in the oral group (P = .001), but did not change with intravenous ibuprofen (P = .4).
CONCLUSIONS: Oral ibuprofen is more effective than intravenous ibuprofen for ductal closure in VLBW infants. The increase in the cystatin-C level with oral treatment suggests that patients with borderline renal function should be evaluated and followed closely.
Tulin Gokmen; Omer Erdeve; Nahide Altug; Serife Suna Oguz; Nurdan Uras; Ugur Dilmen
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-11-20
Journal Detail:
Title:  The Journal of pediatrics     Volume:  158     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-05-26     Revised Date:  2012-01-30    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-554.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Zekai Tahir Burak Maternity Teaching Hospital, Neonatal Intensive Care Unit, Ankara, Turkey.
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MeSH Terms
Administration, Oral
Bilirubin / blood
Cyclooxygenase Inhibitors / administration & dosage*
Cystatin C / blood
Ductus Arteriosus, Patent / drug therapy*,  ultrasonography
Echocardiography, Doppler
Ibuprofen / administration & dosage*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight
Infusions, Intravenous
Kidney Function Tests
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Cystatin C; 15687-27-1/Ibuprofen; 635-65-4/Bilirubin
Comment In:
J Pediatr. 2012 Jan;160(1):179-80; author reply 180   [PMID:  22056351 ]
Erratum In:
J Pediatr. 2012 Jan;160(1):181

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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