| Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus. | |
| | |
MedLine Citation:
|
PMID: 21094951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare oral ibuprofen with intravenous ibuprofen for closure of patent ductus arteriosus in very low birth weight (VLBW) preterm infants. STUDY DESIGN: In a prospective, randomized study, 102 VLBW preterm infants with patent ductus arteriosus received either intravenous or oral ibuprofen at an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 hours. The success rate and evaluation of renal tolerance using cystatin-C were the major outcomes. RESULTS: Patent ductus arteriosus closure rate was significantly higher with oral ibuprofen (84.6% versus 62%) after the first course of the treatment (P = .011). The cystatin-C level increased significantly after treatment in the oral group (P = .001), but did not change with intravenous ibuprofen (P = .4). CONCLUSIONS: Oral ibuprofen is more effective than intravenous ibuprofen for ductal closure in VLBW infants. The increase in the cystatin-C level with oral treatment suggests that patients with borderline renal function should be evaluated and followed closely. |
| | |
Authors:
|
Tulin Gokmen; Omer Erdeve; Nahide Altug; Serife Suna Oguz; Nurdan Uras; Ugur Dilmen |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-11-20 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-15 Completed Date: 2011-05-26 Revised Date: 2012-01-30 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 549-554.e1 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
|
Zekai Tahir Burak Maternity Teaching Hospital, Neonatal Intensive Care Unit, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Bilirubin / blood Cyclooxygenase Inhibitors / administration & dosage* Cystatin C / blood Ductus Arteriosus, Patent / drug therapy*, ultrasonography Echocardiography, Doppler Humans Ibuprofen / administration & dosage* Infant, Newborn Infant, Premature Infant, Premature, Diseases / drug therapy* Infant, Very Low Birth Weight Infusions, Intravenous Kidney Function Tests Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Cyclooxygenase Inhibitors; 0/Cystatin C; 15687-27-1/Ibuprofen; 635-65-4/Bilirubin |
| Comments/Corrections | |
Comment In:
|
J Pediatr. 2012 Jan;160(1):179-80; author reply 180
[PMID:
22056351
]
|
Erratum In:
|
J Pediatr. 2012 Jan;160(1):181 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simple high pH liquid chromatography-tandem mass spectrometry method for basic compounds: Applicat...
Next Document: Mental, Motor, and Language Development of Toddlers with Neurofibromatosis Type 1.