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Efficacy and Safety of the Combination Imidacloprid 10 % / moxidectin 1.0 % Spot-on (Advocate(®) Spot-on for Small Cats and Ferrets) in the Treatment of Ear Mite Infection (Otodectes cynotis) in Ferrets.
MedLine Citation:
PMID:  21739384     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). The study was performed as a multicentre, non-randomised, non-controlled (all study animals were treated) and non-blinded clinical field study in two French veterinary practices. Four visits (day (D) 0 = inclusion and first treatment, D14 = second treatment, D28 = possible third treatment, D56 = termination) were planned. The dosage was one pipet per ferret (designed for cats weighing up to 4 kg, corresponding to a dose of moxidectin ranging from 2.2 to 5 mg/kg body weight) two or three times at 14-days intervals (at D0, D14 and possibly D28 depending on the parasitological examination of the ears at D28). The main efficacy criterion was the absence of the parasite (all stages incl. eggs, larvae, nymphs and adults) from ear scrapings by microscopic examination. At D28 after two treatments (D0 and D14), 76.9 % (30/39) of animals were cured. Only 23 % (9/39) needed a third treatment. At day 56, 100 % were cured. Local symptoms (inflammation and pruritus) were consistently improved (50.6 % improvement at D14, 81.0 % at D28 and 97.9 % at D56) as well as the abnormal cerumen production (14.7 % improvement at D14, 77.7 % at D28 and 100.0 % at D56). No general symptoms were noticed during the study (general health and skin aspect). Advocate(®) spot-on for small cats and ferrets is an effective and safe treatment for ear mite infection in ferrets. Two or three treatments administered in 14-days intervals to ferrets infested with ear mites provided 100 % parasitological cure on D56.
Authors:
Christophe Le Sueur; Sophie Bour; Roland Schaper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parasitology research     Volume:  109 Suppl 1     ISSN:  1432-1955     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Affiliation:
Bayer Santé Division Santé Animale, Puteaux, France, christophe.lesueur@bayer.com.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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