| Efficacy and Safety of Angiotensin II Type 1 Receptor Blocker/Calcium Channel Blocker Combination Therapy for Hypertension: Focus on a Single-pill Fixed-dose Combination of Valsartan and Amlodipine. | |
| | |
MedLine Citation:
|
PMID: 22429340 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Adequate lowering of blood pressure reduces the risk of hypertension-induced cardiovascular events. Worldwide, blood pressure is not optimally controlled and more effective management is needed. The efficacy and tolerability of angiotensin II type 1 receptor blockers (ARBs) have led to their widespread use. Calcium channel blockers (CCBs) are highly effective antihypertensives and amlodipine has a long half-life in the circulation. The combination of an ARB with a CCB as a single-pill, fixed-dose treatment is emerging as possibly the best therapy for preventing cardiovascular disease. Although many kinds of ARB are used in such combinations, amlodipine is mainly used as the CCB. Thus, differences in safety and efficacy among single-pill ARB/CCBs depend mainly on the ARB. Not all ARBs have the same effects and some of these may be molecular (or differential) rather than class (or common) effects. This review discusses the safety and efficacy of ARB/CCB combination therapy, with particular focus on a single-pill, fixed-dose combination of valsartan/amlodipine. |
| | |
Authors:
|
S Miura; K Saku |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of international medical research Volume: 40 ISSN: 1473-2300 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-03-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
|
Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA miuras@cis.fukuoka-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential effects of environment on potato phenylpropanoid and carotenoid expression.
Next Document: Angiotensin Receptor Blockers in Clinical Practice - Implications of the ONTARGET Study.