| Efficacy of Rho-Kinase inhibitor fasudil in secondary Raynaud's phenomenon. | |
| | |
MedLine Citation:
|
PMID: 22275160 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE.: TheRhoA/Rho-kinase pathway plays a pivotal role in cold induced vasoconstriction, vascular smooth muscle cells function and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho-kinase inhibitor, to reverse cold-induced vasospasm in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc). METHODS.: This is a single-center, double-blind, placebo-controlled, randomized, 3-period crossover study of oral fasudil (40mg or 80mg) or placebo administered 2 hours before a standardized cold challenge. The fall in skin temperature after the cold challenge and time to recover 50% and 70% of pre-challenge digital skin temperature were used as primary outcomes. Digital blood flow assessed by Laser Doppler, time to minimum skin temperature, and rate of skin cooling were also measured. RESULTS.: Seventeen patients with SSc and RP completed the study. After cold challenge, skin temperatures and the average time (minutes) to recover 50% (placebo: 7.9, fasudil 40mg: 7.5, and fasudil 80mg: 8.2; p=.791) and 70% (placebo: 18.2, fasudil 40mg: 15.0, and fasudil 80mg: 17.1; p=.654) of pre-challenge skin temperaturewerenot significantly different across the three groups. The digital blood flow measurements were higher in fasudil treated groups than placebo but differences were not significant (p=.693). CONCLUSIONS.: Fasudil administered at single oral dose of 40mg or 80mg was not associated with significant benefit in term of skin temperature recovery time and digital blood flow after cold challenge. © 2012 by the American College of Rheumatology. |
| | |
Authors:
|
Andrea Fava; Peter K Wung; Fredrick M Wigley; Laura K Hummers; Natalie R Daya; Sharon R Ghazarian; Francesco Boin M D |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: Arthritis care & research Volume: - ISSN: 2151-4658 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 by the American College of Rheumatology. |
Affiliation:
|
Johns Hopkins University School of Medicine, Baltimore, MD. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-8738...
Next Document: VEGF(165) b in the developing vasculatures of the fetal human eye.