Document Detail


Efficacy of reversal of aortic calcification by chelating agents.
MedLine Citation:
PMID:  23963635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elastin-specific medial vascular calcification, termed "Monckeberg's sclerosis," has been recognized as a major risk factor for various cardiovascular events. We hypothesize that chelating agents, such as disodium ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and sodium thiosulfate (STS) might reverse elastin calcification by directly removing calcium from calcified tissues into soluble calcium complexes. We assessed the chelating ability of EDTA, DTPA, and STS on removal of calcium from hydroxyapatite (HA) powder, calcified porcine aortic elastin, and calcified human aorta in vitro. We show that both EDTA and DTPA could effectively remove calcium from HA and calcified tissues, while STS was not effective. The tissue architecture was not altered during chelation. In the animal model of aortic elastin-specific calcification, we further show that local periadventitial delivery of EDTA loaded in to poly(lactic-co-glycolic acid) nanoparticles regressed elastin-specific calcification in the aorta. Collectively, the data indicate that elastin-specific medial vascular calcification could be reversed by chelating agents.
Authors:
Yang Lei; Arjun Grover; Aditi Sinha; Naren Vyavahare
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Calcified tissue international     Volume:  93     ISSN:  1432-0827     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-21     Completed Date:  2014-07-01     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Aortic Diseases / drug therapy*,  pathology
Calcium / metabolism
Chelating Agents / pharmacology,  therapeutic use*
Drug Evaluation, Preclinical
Edetic Acid / pharmacology,  therapeutic use
Female
Humans
Male
Middle Aged
Pentetic Acid / pharmacology,  therapeutic use
Rats
Rats, Sprague-Dawley
Swine
Treatment Outcome
Vascular Calcification / drug therapy*,  pathology
Grant Support
ID/Acronym/Agency:
P20 GM103444/GM/NIGMS NIH HHS; P20 RR021949/RR/NCRR NIH HHS; P20GM103444/GM/NIGMS NIH HHS; R01 HL061652/HL/NHLBI NIH HHS; R01 HL070969/HL/NHLBI NIH HHS; R01HL061652/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Chelating Agents; 7A314HQM0I/Pentetic Acid; 9G34HU7RV0/Edetic Acid; SY7Q814VUP/Calcium
Comments/Corrections

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