| Efficacy of radiofrequency ablation in the treatment of small functional adrenal neoplasms. | |
| | |
MedLine Citation:
|
PMID: 20980448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the use of radiofrequency (RF) ablation as a primary treatment for symptomatic primary functional adrenal neoplasms and determine the efficacy of treatment with use of clinical and biochemical follow-up. MATERIALS AND METHODS: After obtaining institutional review board approval, the authors retrospectively evaluated images and medical records from 13 consecutive patients with symptomatic functional adrenal neoplasms (<3.2 cm in diameter) who underwent RF ablation during a 7-year period. There were six men and seven women with a mean age of 54.1 years (range, 42-71 years). Cross-sectional images, findings from clinical examination, and adrenal biochemical markers were available for all patients. Ten of the 13 patients (77%) had an aldosteronoma and one patient each had a cortisol-secreting tumor, testosterone-secreting tumor, and pheochromocytoma. RF ablation was performed by two radiologists using an internally cooled electrode and a pulsed technique according to manufacturer's specifications. Clinical and laboratory follow-up was performed for all patients. Three patients underwent imaging follow-up for other reasons. RESULTS: All patients demonstrated resolution of abnormal biochemical markers after ablation (mean biochemical follow-up, 21.2 months). In addition, all patients experienced resolution of clinical symptoms or syndromes, including hypertension and hypokalemia (in patients with aldosteronoma), Cushing syndrome (in the patient with cortisol-secreting tumor), virilizing symptoms (in the patient with testosterone-secreting tumor), and hypertension (in the patient with pheochromocytoma). For the patients with aldosteronoma, improvements in hypertension management were noted. The mean blood pressure before ablation was 149/90 mm Hg with a mean (±standard deviation) of 3.1 ± 0.6 blood pressure medications, and this decreased to 122/77 mm Hg at a mean of 2.8 months after ablation with 1.3 ± 0.9 medications (P < .001) and 124/75 mm Hg at a mean of 41.4 months. There were two minor complications: one small pneumothorax and one limited hemothorax, neither of which required overnight admission. There were two episodes of transient self-remitting procedural hypertension-one in a patient with aldosteronoma and one in the patient with a cortisol-secreting tumor; however, none of these patients required further therapy during overnight observation. CONCLUSION: RF ablation may be an effective, minimally invasive method for treating small functional primary adrenal tumors. |
| | |
Authors:
|
Mishal Mendiratta-Lala; Darren D Brennan; Olga R Brook; Salomao Faintuch; Peter M Mowschenson; Robert G Sheiman; S Nahum Goldberg |
Related Documents
:
|
12843148 - Four-year treatment with octreotide-long-acting repeatable in 110 acromegalic patients:... 17805568 - Pituitary height and neuroradiological alterations in patients with prader-labhart-will... 2260448 - Who is treated with growth hormone today? the executive scientific committee of the kab... 12053088 - Dehydroepiandrosterone sulfate and growth axis hormones in patients with ischemic heart... 22974118 - Demographics, socio-economic characteristics, and risk factor prevalence in patients wi... 1774958 - Diagnostic and prognostic values of in vitro culture growth patterns of marrow granuloc... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-27 |
Journal Detail:
|
Title: Radiology Volume: 258 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-24 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 308-16 Citation Subset: AIM; IM |
Copyright Information:
|
© RSNA, 2010 |
Affiliation:
|
Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA. mishal_lala@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Gland Neoplasms
/
surgery* Adult Aged Catheter Ablation / methods* Female Humans Male Middle Aged Radiography, Interventional Retrospective Studies Treatment Outcome Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Advanced hepatocellular carcinoma: early evaluation of response to bevacizumab therapy at dynamic co...
Next Document: Renal arteries: isotropic, high-spatial-resolution, unenhanced MR angiography with three-dimensional...