Document Detail

Efficacy of multi-staged surgery and adjuvant chemotherapy for successful treatment of atypical choroid plexus papilloma in an infant: case report.
MedLine Citation:
PMID:  19855149     Owner:  NLM     Status:  MEDLINE    
A 12-month-old girl presented with a rare atypical choroid plexus papilloma manifesting as conscious disturbance and vomiting. Magnetic resonance (MR) imaging revealed a well-delineated 5 x 6-cm lobulate mass in the right lateral ventricle. Only partial removal of the tumor was performed because of excessive intraoperative hemorrhage at the first surgery. The histological diagnosis was atypical choroid plexus papilloma. To control the intraoperative hemorrhage, embolization of the feeding artery was performed before the second surgery, and the tumor was macroscopically totally removed. MR imaging disclosed a small residual tumor which showed relatively rapid growth. The patient underwent the third removal 5 months after the second surgery. Two months later, MR imaging showed a cystic lesion with a small nodule adjacent to the midbrain, indicating dissemination of the tumor. The lesion was successfully treated with chemotherapy. Atypical choroid plexus papilloma was recently defined in the classification of the World Health Organization, so clinical data based on these criteria are lacking to establish the therapeutic strategy. Total resection of atypical choroid plexus papilloma is the most reliable treatment at present. However, postoperative chemotherapy should be considered for recurrence or dissemination.
Mayu Takahashi; Junkoh Yamamoto; Yuichi Aoyama; Yositeru Soejima; Daisuke Akiba; Shigeru Nishizawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  49     ISSN:  1349-8029     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  484-7     Citation Subset:  IM    
Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain / blood supply,  pathology,  surgery*
Cerebral Arteries / pathology,  physiopathology
Embolization, Therapeutic
Intraoperative Complications / etiology,  physiopathology,  therapy
Lateral Ventricles / blood supply,  pathology,  surgery*
Lethargy / etiology
Magnetic Resonance Imaging
Neoplasm Metastasis / drug therapy,  pathology
Neurosurgical Procedures
Papilloma, Choroid Plexus / drug therapy*,  pathology,  surgery*
Postoperative Hemorrhage / etiology,  physiopathology,  therapy
Tomography, X-Ray Computed
Treatment Outcome
Vomiting / etiology

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